Selected Publications

  1. Li LC. Chromatin remodeling by the small RNA machinery in mammalian cells. Epigenetics 2013 Oct 22;9(1). PDF
  2. Huang V, Zheng J, Qi, Z, Wang J, Place R, Yu J, Li H, Li LC. Ago1 interacts with RNA polymerase II and binds to the promoters of actively transcribed genes in human cancer cells. PLoS Genet 2013 Sep;9(9):e1003821. doi: 10.1371/journal.pgen.1003821. Epub 2013 Sep 26. PDF
  3. Ren S, Kang MR, Wang J, Huang V, Place RF, Sun Y, Li LC. Targeted induction of endogenous NKX3-1 by small activating RNA inhibits prostate tumor growth. Prostate 2013 Jul 8. doi: 10.1002/pros.22709. PDF
  4. Kosaka M, Kang MR, Yang G, Li LC. Targeted p21WAF1/CIP1 activation by RNAa inhibits hepatocellular carcinoma cells. Nucleic Acid Ther 2012 Oct;22(5):335-43. doi: 10.1089/nat.2012.0354. Epub 2012 Aug 21.
  5. Wang T, Li M, Yuan H, Zhan Y, Xu H, Wang S, Yang W, Liu J, Ye Z, Li LC. Small activating RNA-guided iNOS up-regulation improves erectile function of diabetic rats. J Urol 2013 Mar 19. doi:pii: S0022-5347(13)03690-2. 10.1016/j.juro.2013.03.043. PDF
  6. Kang MR, Yang G, Place RF, Charisse K, Epstein-Barash H, Manoharan M, Li LC. Intravesical delivery of small activating RNA formulated into lipid nanoparticles inhibits orthotopic bladder tumor growth. Cancer Res 2012 Oct 1;72(19):5069-79. doi: 10.1158/0008-5472.CAN-12-1871. Epub 2012 Aug 6. PDF
  7. Kang MR, Yang G, Charisse K, Epstein-Barash H, Manoharan M, Li LC.An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment. J Vis Exp 2012 Jul 28;(65). pii: 4207. doi: 10.3791/4207.
  8. Place RF, Wang J, Noonan E, Meyers R, Manoharan M, Charisse K, Duncan R, Huang V, Wang X and Li LC. Formulation of small activating RNA into lipidoid nanoparticles inhibits xenograft prostate tumor growth by inducing p21 expression. Molecular Therapy - Nucleic Acids 2012; 1, e15; doi:10.1038/mtna.2012.5. PDF
  9. Wang X, Wang J, Huang V, Place RF, and Li LC. Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation. Biochem J 2012 Feb 17. [Epub ahead of print]. PDF
  10. Huang V and Li LC. miRNA goes nuclear. RNA Biology 2012 Mar 1;9(3). [Epub ahead of print]. PDF or Full text paper at PMC
  11. Wang J, Li LC. Small RNA and its application in andrology and urology . Transl Androl Urol 2011 Dec 29. DOI: 10.3978/ j.issn.2223-4683.2011.12.04. PDF
  12. Huang V, Place RF,Portnoy V, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J, Li LC. Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nuclear Acids Research 2011 Nov 3. [Epub ahead of print]. PDF
  13. Portnoy V, Huang V, Place RF, Li LC. Small RNA and transcriptional upregulation. Wiley Interdiscip Rev RNA 2011 Sep;2(5):748-60. doi: 10.1002/wrna.90. Epub 2011 May 2. PDF or PDF from PMC
  14. Wang J, Place RF, Huang V, Wang X, Noonan EJ, Magyar CE, Huang J, Li LC. Prognostic value and function of KLF4 in prostate cancer: RNAa and vector-mediated overexpression identify KLF4 as an inhibitor of tumor cell growth and migration. Cancer Res 2010 Dec 15;70(24):10182-91. PDF
  15. Noonan EJ, Place RF, Basak S, Pookot D, Li LC. miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells. Oncotarget 2010 Sep;1(5):349-58. PDF
  16. Place RF, Noonan EJ, Földes-Papp Z, Li LC. Defining features and exploring chemical modifications to manipulate RNAa activity. Curr Pharm Biotechnol. 2010 Aug;11(5):518-26. PDF
  17. Lin G, Yang R, Banie L, Wang G, Ning H, Li LC, Lue TF, Lin CS. Effects of transplantation of adipose tissue-derived stem cells on prostate tumor. Prostate 2010 Mar 15. [Epub ahead of print]
  18. Huang V, Qin Y, Wang J, Wang X, Place RF, Lin GT, Lue TF, Li LC. RNAa is conserved in mammalian cells. PLoS ONE. 2010 5(1): e8848. doi:10.1371/journal.pone.0008848. PDF
  19. Ning H, Huang YC, Banie L, Hung S, Lin G, Li LC, Lue TF, Lin CS. MicroRNA regulation of neuron-like differentiation of adipose tissue-derived stem cells. Differentiation. 2009 Dec;78(5):253-9. Epub 2009 Aug 19.
  20. Ning H, Liu G, Lin G, Garcia M, Li LC, Lue TF, Lin CS. Identification of an aberrant cell line among human adipose tissue-derived stem cell isolates. Differentiation. 2009 Feb;77(2):172-80. Epub 2008 Oct 21.
  21. Dharap A, Bowen K, Place R, Li LC, Vemuganti R. Transient focal ischemia induces extensive temporal changes in rat cerebral MicroRNAome.J Cereb Blood Flow Metab 2009 Jan 14. [Epub ahead of print]
  22. Li LC. The multifaceted small RNAs. RNA Biol. 2008 Mar 29;5(2) [Epub ahead of print]. PDF
  23. Chen Z, Place RF, Jia ZJ, Pookot D, Dahiya R, Li LC. Antitumor effect of dsRNA-induced p21WAF1/CIP1 gene activation in human bladder cancer cells. Mol Cancer Ther. 2008 Mar;7(3):698-703. PDF
  24. Place RF, Li LC, Pookot D, Noonan EJ, Dahiya R. MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1608-13. Epub 2008 Jan 28.
  25. Li LC. Designing PCR primer for DNA methylation mapping. Methods Mol Biol 2007;402:371-84
  26. Li LC, Okino ST, Zhao H, Pokot D, Place RF, Dahiya R. Small double-stranded RNAs induce transcriptional activation in human cells. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17337-17342.
  27. Li LC, Carroll PR, and Dahiya R. Epigenetic changes in prostate cancer: implication for diagnosis and treatment. J Natl Cancer Inst. 2005 Jan 19;97(2):103-15.
  28. Li LC, Shiina H, Deguchi M, Zhao H, Okino ST, Kane CJ, Carroll PR, Igawa M and Dahiya R. Age-dependent methylation of estrogen receptor alpha in prostate cancer. Biochem Biophys Res Commun 2004 Aug; 20 321(2):455-461.
  29. Li LC, Okino ST and Dahiya R. DNA methylation in prostate cancer. Biochim Biophys Acta Reviews on Cancer 2004 Sep 20;1704(2):87-102.
  30. Li LC, Zhao H, Shiina H, Kane CJ and Dahiya R. PGDB: a curated and integrated database of genes related to the prostate. Nucleic Acids Research 2003, Jan 1;31(1):291-3.
  31. Li LC and Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics 2002;18:1-5.
  32. Li LC, Zhao H, Nakajima K, Oh BR, Filho LA, Carroll PR, Dahiya R. Methylation of the E-cadherin gene promoter correlates with progression of prostate cancer. J Urol 2001 Aug;166(2):705-9.
  33. Li LC, Yeh CC, Nojima D, Dahiya R. Cloning and characterization of human estrogen receptor beta promoter. Biochem Biophys Res Commun. 2000 Aug 28;275(2):682-9.
  34. Li LC, Chui RM, Sasaki M, Nakajima K, Perinchery G, Au HC, Nojima D, Carroll PR, Dahiya R: A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities. Cancer Res 2000 Feb 15;60(4):873-6.
  35. Li LC, Chui R, Nakajima K, Oh BR, Au HC, Dahiya R: Frequent methylation of estrogen receptor in prostate cancer: correlation with tumor progression. Cancer Res 2000 Feb 1;60(3):702-6.