My laboratory is interested in understanding the nuclear function of small noncoding RNAs (ncRNAs) such as microRNAs in mammalian cells. Small ncRNAs exist, with some highly enriched, in the nucleus. However, little is known about their nuclear function. We are taking a genome-wide approach to study how they regulate transcription and and modulate chromatin structure, and by doing so, how they play a role in basic cellular processes such as differentiation and in diseases such as cancer.