| Name | cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 |
| Symbol | CYP3A4 |
| Aliases | CP34; NF-25; P450C3; P450PCN1; nifedipine oxidase; P450-III, steroid inducible; glucocorticoid-inducible P450 |
| Gene Product | - cytochrome P450, subfamily IIIA, polypeptide 4
|
| Category | - Mutation in Prostate cancer
|
| UniGene | Hs.178738 |
| OMIM | 124010 |
| Locus | 1576 |
| Summary | This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. |
| Gene Ontology | |
| Expression | | EST (165 ESTs, 13 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| gall (1/3) |  | 2/2502 |
| kidney (1/86) | | 3/132968 |
| liver (3/38) | | 60/46472 |
| uncharacterized tissue (8/1773) | | 100/713325 |
|
| SAGE (1572214 tags, 30 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| brain (4/19) | | 4/199003 |
| colon (4/8) | | 4/229478 |
| eye (3/6) | | 3/261337 |
| foreskin (1/2) | | 1/9497 |
| lung (1/1) | | 7/89143 |
| mammary gland (5/19) | | 5/244421 |
| ovary (3/10) | | 3/99746 |
| prostate (2/13) |  | 4/253010 |
| skin (1/7) | | 1/10080 |
| uncharacterized tissue (4/22) | | 4/176499 |
|
|
| SNP | rs2738258 (G/T:intron); rs1851426 (C/T:locus-region); rs3039454 (GC/-:intron); rs2405184 (A/G:intron); rs2253493 (T/C:intron); rs2242480 (C/T:intron); rs1041966 (T/C:coding-nonsyn); rs3091339 (G/C:intron); rs2740573 (C/T:mrna-utr); rs2253498 (C/T:intron); rs2687104 (A/G:intron); rs2246709 (A/G:intron); |
| Evidence | Mutation in Prostate cancer
|
