Human Prostate Gene DataBase

Name cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
Symbol CYP3A4
Aliases CP34; NF-25; P450C3; P450PCN1; nifedipine oxidase; P450-III, steroid inducible; glucocorticoid-inducible P450
Gene Product
  • cytochrome P450, subfamily IIIA, polypeptide 4
  • Mutation in Prostate cancer
SummaryThis gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.
Gene Ontology
EST (165 ESTs, 13 libraries)
Tissue ? Frequency ? Count ?
gall (1/3)0.380 2/2502
kidney (1/86)0.023 3/132968
liver (3/38)1.000 60/46472
uncharacterized tissue (8/1773)0.279 100/713325
SAGE (1572214 tags, 30 libraries)
Tissue ? Frequency ? Count ?
brain (4/19)0.176 4/199003
colon (4/8)0.098 4/229478
eye (3/6)0.089 3/261337
foreskin (1/2)1.000 1/9497
lung (1/1)0.746 7/89143
mammary gland (5/19)0.223 5/244421
ovary (3/10)0.219 3/99746
prostate (2/13)0.213 4/253010
skin (1/7)0.314 1/10080
uncharacterized tissue (4/22)0.195 4/176499
SNPrs2738258 (G/T:intron);  rs1851426 (C/T:locus-region);  rs3039454 (GC/-:intron);  rs2405184 (A/G:intron);  rs2253493 (T/C:intron);  rs2242480 (C/T:intron);  rs1041966 (T/C:coding-nonsyn);  rs3091339 (G/C:intron);  rs2740573 (C/T:mrna-utr);  rs2253498 (C/T:intron);  rs2687104 (A/G:intron);  rs2246709 (A/G:intron);  
EvidenceMutation in Prostate cancer

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Department of Urology
Universityof California, San Francisco