Human

Human Prostate Gene DataBase
Name kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
Symbol KAI1
Aliases R2; 4F9; C33; IA4; ST6; CD82; GR15; SAR2; CD82 antigen; R2 leukocyte antigen; suppressor of tumorigenicity 6
Gene Product
  • kangai 1
Category
  • Gross deletion in Prostate cancer
  • Methylation in Prostate cancer
  • Mutation in Prostate cancer
UniGeneHs.323949
OMIM600623
Locus3732
SummaryThis metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients.
Gene Ontology
Expression
EST (252 ESTs, 117 libraries)
Tissue ? Frequency ? Count ?
adipose (1/10)0.131 1/2445
adrenal gland (1/15)0.012 1/17521
b cells (1/1)0.068 14/16734
blood (2/27)0.032 7/40686
bone (1/13)0.139 1/26211
brain (11/204)0.010 13/362011
cartilage (1/5)0.026 1/11018
colon (6/853)0.110 33/165626
embryo (1/19)0.058 4/37976
esophagus (1/6)0.029 1/3022
eye (1/33)0.010 1/93836
foreskin (1/4)0.008 2/20040
germ cell (1/7)0.009 1/57383
head and neck (7/990)0.310 10/79796
intestine (1/4)0.007 1/11528
kidney (6/86)0.034 15/132968
lung (7/312)0.030 17/245386
muscle (2/21)0.015 11/71297
oral cavity (1/18)0.004 2/44567
ovary (5/144)0.013 7/81880
pancreas (7/33)0.008 19/117255
parathyroid (1/4)0.029 7/19377
placenta (4/342)0.023 11/157762
prostate (3/291)0.014 6/109871
skin (6/31)0.156 11/100815
spleen (1/7)0.040 1/9511
stomach (5/312)0.074 11/129930
testis (1/171)0.004 2/117531
thyroid (1/24)0.466 1/6853
uncharacterized tissue (23/1773)0.013 28/713325
uterus (7/212)1.000 12/155110
SAGE (10371191 tags, 193 libraries)
Tissue ? Frequency ? Count ?
brain (17/19)0.274 45/2113680
cerebellum (1/1)1.000 4/205120
colon (7/8)0.302 18/789162
eye (4/6)0.313 15/863677
heart (1/1)0.380 6/168714
kidney (1/2)0.345 3/125571
liver (1/1)0.208 5/133722
lung (1/1)0.369 6/267429
mammary gland (12/19)0.927 90/1001838
muscle (2/2)0.186 3/161581
ovary (8/10)0.836 71/521405
pancreas (7/8)0.984 72/510942
prostate (11/13)0.261 24/1139230
skin (2/7)0.207 2/37633
stomach (2/3)0.347 8/409395
uncharacterized tissue (14/22)0.414 45/1367264
vascular (3/3)0.445 12/554828
SNPrs2115665 (A/G:intron);  rs883752 (C/T:coding-nonsyn);  rs934175 (A/G:locus-region);  rs2082053 (T/C:mrna-utr);  rs744630 (C/G:mrna-utr);  rs2863106 (A/G:intron);  rs1344709 (A/G:mrna-utr);  rs2115670 (G/T:mrna-utr);  rs3051240 (-/TTTTT:intron);  rs1981992 (C/G:mrna-utr);  rs891307 (C/T:intron);  rs891303 (A/G:intron);  rs1560296 (A/G:mrna-utr);  rs730129 (C/T:mrna-utr);  rs891305 (C/T:mrna-utr);  rs1864297 (A/T:mrna-utr);  rs2303861 (T/C:coding-nonsyn);  rs2163094 (C/G:mrna-utr);  rs2099140 (C/T:mrna-utr);  rs2902412 (C/G:mrna-utr);  rs919444 (C/T:intron);  rs744222 (A/C:mrna-utr);  rs1063031 (G/A:mrna-utr);  
EvidenceGross deletion in Prostate cancer Methylation in Prostate cancer Mutation in Prostate cancer
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Department of Urology
Universityof California, San Francisco