Human Prostate Gene DataBase

Name retinoic acid receptor, beta
Symbol RARB
Aliases HAP; RRB2; NR1B2; RAR-epsilon; RAR, beta form; HBV-activated protein; retinoic acid receptor beta 2; retinoic acid receptor beta 4; hepatitis B virus activated protein; retinoic acid receptor, beta polypeptide
Gene Product
  • retinoic acid receptor, beta isoform 1
  • retinoic acid receptor, beta isoform 2
  • Methylation in Prostate cancer
SummaryThis gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined.
Gene Ontology
EST (66 ESTs, 34 libraries)
Tissue ? Frequency ? Count ?
brain (2/204)0.019 10/362011
colon (1/853)0.022 2/165626
ear (1/2)0.007 1/12660
embryo (1/19)0.008 2/37976
eye (3/33)0.049 6/93836
gall (1/3)0.417 1/2502
germ cell (2/7)0.005 3/57383
head and neck (1/990)1.000 1/79796
heart (1/22)0.005 2/55494
kidney (4/86)0.015 9/132968
liver (1/38)0.011 1/46472
lung (1/312)0.021 1/245386
ovary (2/144)0.021 3/81880
pancreas (1/33)0.010 1/117255
placenta (1/342)0.008 2/157762
testis (1/171)0.002 1/117531
umbilical cord (1/3)0.030 2/6185
uncharacterized tissue (8/1773)0.003 17/713325
uterus (1/212)0.005 1/155110
SAGE (7727528 tags, 145 libraries)
Tissue ? Frequency ? Count ?
blood (1/1)0.213 1/48523
brain (18/19)0.501 64/1820116
cerebellum (1/1)0.302 2/102560
colon (6/8)0.455 18/613072
eye (6/6)1.000 43/928740
heart (1/1)0.326 4/84357
kidney (2/2)0.327 4/115792
mammary gland (10/19)0.348 19/618945
muscle (1/2)0.383 1/53875
ovary (7/10)0.911 20/435957
pancreas (5/8)0.654 12/287249
prostate (10/13)0.284 18/786774
stomach (3/3)0.395 10/227799
uncharacterized tissue (14/22)0.601 48/1230267
vascular (3/3)0.395 10/373502
SNPrs1864905 (C/T:intron);  rs1975250 (A/G:intron);  rs1656452 (C/G:intron);  rs1631354 (G/A:intron);  rs1303630 (A/C:intron);  rs1864907 (A/G:intron);  rs1369603 (C/G:intron);  rs1626875 (T/C:intron);  rs2915746 (A/G:intron);  rs1968481 (A/G:intron);  rs1299017 (G/A:intron);  rs2278480 (T/C:intron);  rs2164360 (C/T:intron);  rs1992005 (C/T:intron);  rs1881703 (C/T:intron);  rs868367 (C/T:intron);  rs1290443 (G/A:intron);  rs1299407 (G/A:intron);  rs3074677 (-/TTT:intron);  rs2056777 (C/T:intron);  rs1483856 (A/C:intron);  rs1347458 (G/T:intron);  rs2067964 (T/G:intron);  rs1435701 (A/T:intron);  rs2568875 (A/G:intron);  rs1997351 (A/G:intron);  rs1286733 (A/G:intron);  rs1529099 (A/G:intron);  rs1865613 (A/G:intron);  rs2364120 (C/G:intron);  rs755661 (C/T:intron);  rs1297795 (G/A:intron);  rs1296109 (A/C:intron);  rs1286641 (G/A:intron);  rs1298215 (G/A:intron);  rs1816526 (C/T:intron);  rs1406575 (A/G:intron);  rs1560633 (C/T:intron);  rs1294660 (C/T:intron);  rs957950 (A/G:intron);  rs955979 (T/G:intron);  rs1965773 (G/T:intron);  rs2023199 (A/C:intron);  rs2116703 (G/A:intron);  rs1286749 (G/C:intron);  rs1730218 (G/T:intron);  rs1835901 (A/T:intron);  rs1368264 (C/T:intron);  rs1529875 (C/G:intron);  rs2886124 (C/G:intron);  rs2053023 (A/G:intron);  rs2698516 (C/G:intron);  rs1529673 (A/G:intron);  rs1561032 (G/T:intron);  rs1153582 (A/G:intron);  
EvidenceMethylation in Prostate cancer

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Department of Urology
Universityof California, San Francisco