| Name | retinoic acid receptor, beta |
| Symbol | RARB |
| Aliases | HAP; RRB2; NR1B2; RAR-epsilon; RAR, beta form; HBV-activated protein; retinoic acid receptor beta 2; retinoic acid receptor beta 4; hepatitis B virus activated protein; retinoic acid receptor, beta polypeptide |
| Gene Product | - retinoic acid receptor, beta isoform 1
- retinoic acid receptor, beta isoform 2
|
| Category | - Methylation in Prostate cancer
|
| UniGene | Hs.171495 |
| OMIM | 180220 |
| Locus | 5915 |
| Summary | This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined. |
| Gene Ontology | |
| Expression | | EST (66 ESTs, 34 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| brain (2/204) |  | 10/362011 |
| colon (1/853) | | 2/165626 |
| ear (1/2) | | 1/12660 |
| embryo (1/19) | | 2/37976 |
| eye (3/33) | | 6/93836 |
| gall (1/3) | | 1/2502 |
| germ cell (2/7) | | 3/57383 |
| head and neck (1/990) | | 1/79796 |
| heart (1/22) | | 2/55494 |
| kidney (4/86) | | 9/132968 |
| liver (1/38) | | 1/46472 |
| lung (1/312) | | 1/245386 |
| ovary (2/144) | | 3/81880 |
| pancreas (1/33) | | 1/117255 |
| placenta (1/342) | | 2/157762 |
| testis (1/171) | | 1/117531 |
| umbilical cord (1/3) | | 2/6185 |
| uncharacterized tissue (8/1773) | | 17/713325 |
| uterus (1/212) | | 1/155110 |
|
| SAGE (7727528 tags, 145 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/1) | | 1/48523 |
| brain (18/19) | | 64/1820116 |
| cerebellum (1/1) | | 2/102560 |
| colon (6/8) | | 18/613072 |
| eye (6/6) | | 43/928740 |
| heart (1/1) | | 4/84357 |
| kidney (2/2) | | 4/115792 |
| mammary gland (10/19) | | 19/618945 |
| muscle (1/2) | | 1/53875 |
| ovary (7/10) | | 20/435957 |
| pancreas (5/8) | | 12/287249 |
| prostate (10/13) |  | 18/786774 |
| stomach (3/3) | | 10/227799 |
| uncharacterized tissue (14/22) | | 48/1230267 |
| vascular (3/3) | | 10/373502 |
|
|
| SNP | rs1864905 (C/T:intron); rs1975250 (A/G:intron); rs1656452 (C/G:intron); rs1631354 (G/A:intron); rs1303630 (A/C:intron); rs1864907 (A/G:intron); rs1369603 (C/G:intron); rs1626875 (T/C:intron); rs2915746 (A/G:intron); rs1968481 (A/G:intron); rs1299017 (G/A:intron); rs2278480 (T/C:intron); rs2164360 (C/T:intron); rs1992005 (C/T:intron); rs1881703 (C/T:intron); rs868367 (C/T:intron); rs1290443 (G/A:intron); rs1299407 (G/A:intron); rs3074677 (-/TTT:intron); rs2056777 (C/T:intron); rs1483856 (A/C:intron); rs1347458 (G/T:intron); rs2067964 (T/G:intron); rs1435701 (A/T:intron); rs2568875 (A/G:intron); rs1997351 (A/G:intron); rs1286733 (A/G:intron); rs1529099 (A/G:intron); rs1865613 (A/G:intron); rs2364120 (C/G:intron); rs755661 (C/T:intron); rs1297795 (G/A:intron); rs1296109 (A/C:intron); rs1286641 (G/A:intron); rs1298215 (G/A:intron); rs1816526 (C/T:intron); rs1406575 (A/G:intron); rs1560633 (C/T:intron); rs1294660 (C/T:intron); rs957950 (A/G:intron); rs955979 (T/G:intron); rs1965773 (G/T:intron); rs2023199 (A/C:intron); rs2116703 (G/A:intron); rs1286749 (G/C:intron); rs1730218 (G/T:intron); rs1835901 (A/T:intron); rs1368264 (C/T:intron); rs1529875 (C/G:intron); rs2886124 (C/G:intron); rs2053023 (A/G:intron); rs2698516 (C/G:intron); rs1529673 (A/G:intron); rs1561032 (G/T:intron); rs1153582 (A/G:intron); |
| Evidence | Methylation in Prostate cancer
|
