Human

Human Prostate Gene DataBase

Name death-associated protein kinase 1
Symbol DAPK1
Aliases DAPK
Gene Product
  • death-associated protein kinase 1
Category
  • Methylation in Prostate cancer
UniGeneHs.153924
OMIM600831
Locus1612
SummaryDeath-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
Gene Ontology
Expression
EST (157 ESTs, 85 libraries)
Tissue ? Frequency ? Count ?
blood (2/27)0.005 2/40686
bone (1/13)0.004 1/26211
brain (9/204)0.011 21/362011
connective tissue (1/1)0.028 1/1301
embryo (1/19)0.019 1/37976
eye (5/33)0.012 6/93836
germ cell (1/7)0.005 5/57383
heart (1/22)0.003 3/55494
intestine (1/4)0.003 1/11528
kidney (2/86)0.261 2/132968
liver (1/38)0.002 1/46472
lung (5/312)0.011 13/245386
muscle (2/21)0.013 6/71297
nervous (2/475)0.486 2/43438
ovary (2/144)0.008 3/81880
pancreas (4/33)0.002 6/117255
parathyroid (1/4)0.006 3/19377
placenta (16/342)0.157 34/157762
skin (2/31)0.013 2/100815
stomach (2/312)0.115 4/129930
testis (1/171)0.001 1/117531
uncharacterized tissue (18/1773)1.000 32/713325
uterus (4/212)0.004 6/155110
SAGE (5498126 tags, 102 libraries)
Tissue ? Frequency ? Count ?
blood (1/1)0.129 3/48523
brain (14/19)0.194 17/900087
colon (3/8)0.280 5/233459
eye (6/6)0.475 8/453737
heart (1/1)0.148 1/84357
kidney (1/2)0.149 1/41857
liver (1/1)0.093 1/66861
lung (1/1)0.350 3/178286
mammary gland (7/19)0.232 9/496340
ovary (4/10)0.437 5/175415
pancreas (4/8)0.507 9/337619
prostate (5/13)1.000 16/573581
skin (1/7)0.278 1/22466
stomach (2/3)0.592 8/404994
uncharacterized tissue (11/22)0.695 34/1136032
vascular (2/3)0.377 6/344512
SNPrs729958 (C/T:intron);  rs1861827 (C/T:mrna-utr);  rs943854 (A/G:intron);  rs2149377 (G/T:intron);  rs1887792 (A/G:intron);  rs1064221 (T/G:mrna-utr);  rs2068771 (G/A:mrna-utr);  rs1804417 (G/A:mrna-utr);  rs3128524 (A/G:mrna-utr);  rs1927978 (C/T:intron);  rs877861 (C/T:intron);  rs2270404 (G/C:mrna-utr);  rs2378753 (C/T:intron);  rs1927973 (A/G:mrna-utr);  rs1468928 (A/T:mrna-utr);  rs3095753 (C/T:mrna-utr);  rs1007394 (C/T:intron);  rs3118873 (A/G:intron);  rs3031545 (-/CA:intron);  rs2889980 (A/C:intron);  rs2225211 (A/G:mrna-utr);  rs1024883 (C/T:mrna-utr);  rs1056719 (G/A:coding-nonsyn);  rs2183026 (G/T:intron);  rs2282012 (A/C:intron);  rs2042006 (C/G:mrna-utr);  rs3124238 (C/T:mrna-utr);  rs888338 (C/T:mrna-utr);  rs1421000 (A/G:mrna-utr);  rs1015477 (A/C:mrna-utr);  rs3118841 (C/T:mrna-utr);  rs1410577 (C/T:intron);  rs2111554 (T/C:mrna-utr);  rs1558892 (C/T:mrna-utr);  rs884605 (A/G:mrna-utr);  rs2209914 (T/C:intron);  rs3118870 (T/C:intron);  rs2274601 (G/C:mrna-utr);  rs3128470 (A/C:intron);  rs3118867 (A/G:mrna-utr);  rs721936 (A/G:intron);  rs1005090 (C/T:intron);  
EvidenceMethylation in Prostate cancer

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Department of Urology
Universityof California, San Francisco