Human Prostate Gene DataBase

Name fragile histidine triad gene
Symbol FHIT
Aliases FRA3B; AP3Aase; AP3A hydrolase; dinucleosidetriphosphatase; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase
Gene Product
  • fragile histidine triad gene
  • Methylation in Prostate cancer
SummaryThis gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas.
Gene Ontology
EST (81 ESTs, 31 libraries)
Tissue ? Frequency ? Count ?
brain (1/204)0.000 1/362011
colon (1/853)0.000 1/165626
embryo (1/19)0.002 1/37976
eye (2/33)0.001 3/93836
foreskin (1/4)0.000 1/20040
germ cell (1/7)0.000 2/57383
kidney (4/86)0.001 5/132968
lung (2/312)0.000 2/245386
nervous (1/475)0.002 2/43438
pancreas (1/33)0.000 1/117255
placenta (1/342)0.000 1/157762
prostate (1/291)0.000 1/109871
spleen (1/7)0.002 1/9511
stomach (1/312)1.000 9/129930
testis (1/171)0.000 1/117531
uncharacterized tissue (11/1773)0.002 49/713325
SAGE (2177357 tags, 40 libraries)
Tissue ? Frequency ? Count ?
brain (9/19)0.204 13/617412
colon (1/8)0.046 1/57686
eye (1/6)1.000 5/53666
liver (1/1)0.161 1/66861
mammary gland (6/19)0.185 9/322446
ovary (1/10)0.425 2/67350
pancreas (2/8)0.077 2/81018
prostate (5/13)0.315 6/306360
stomach (2/3)0.157 2/136465
uncharacterized tissue (6/22)0.410 7/339346
vascular (2/3)0.052 2/128747
SNPrs812427 (G/C:intron);  rs637319 (T/C:intron);  rs662910 (T/C:intron);  rs635904 (G/T:intron);  rs510015 (C/A:intron);  rs666445 (T/C:intron);  rs17493 (A/G:intron);  rs1905863 (A/C:intron);  rs589792 (C/T:intron);  rs1564912 (A/G:intron);  rs575614 (C/G:intron);  rs167140 (A/G:intron);  rs3074239 (CTTAA/-:mrna-utr);  rs1666057 (C/T:intron);  rs1964583 (C/G:intron);  rs1629023 (C/A:intron);  rs666083 (C/G:intron);  rs529626 (G/T:intron);  rs780374 (G/C:intron);  rs1021227 (A/T:intron);  rs644087 (G/T:intron);  rs597790 (G/C:intron);  rs3112498 (A/T:intron);  rs3100801 (A/G:intron);  rs673870 (C/T:intron);  rs2077774 (A/C:mrna-utr);  rs1385710 (A/G:mrna-utr);  rs650905 (G/A:intron);  rs780935 (T/G:intron);  rs1666092 (C/A:intron);  rs587775 (C/T:intron);  rs562516 (T/C:intron);  rs172455 (T/A:intron);  rs1872494 (G/T:intron);  rs503665 (C/T:mrna-utr);  rs3075168 (-/CA:intron);  rs1960248 (A/C:intron);  rs3047601 (AA/-:intron);  rs1813201 (C/T:intron);  rs616604 (C/G:intron);  rs615964 (G/C:intron);  rs493783 (T/A:intron);  rs1879996 (A/G:intron);  rs575388 (A/G:intron);  rs1630608 (T/A:intron);  rs2736802 (C/T:intron);  rs190899 (T/C:intron);  rs678729 (T/G:intron);  rs677703 (G/A:intron);  rs608582 (A/G:intron);  rs2361333 (A/G:intron);  rs481165 (C/G:intron);  rs3112500 (T/G:intron);  rs621666 (C/T:intron);  rs583363 (C/T:intron);  rs671920 (A/G:intron);  rs482814 (C/G:intron);  rs609891 (T/C:intron);  rs659036 (T/C:intron);  rs1797563 (A/T:intron);  rs602197 (C/T:intron);  rs1456157 (C/T:intron);  rs1319341 (T/G:intron);  rs1159236 (C/G:intron);  rs475675 (G/A:intron);  rs184149 (T/G:intron);  rs510794 (T/C:intron);  rs923141 (C/T:intron);  rs678205 (A/G:intron);  rs672225 (T/G:intron);  rs592763 (A/C:intron);  rs582313 (A/C:intron);  rs684584 (G/A:intron);  rs599542 (C/G:intron);  rs565226 (A/C:intron);  rs678981 (A/G:intron);  rs1983425 (A/T:intron);  rs720000 (A/G:mrna-utr);  rs660097 (A/C:intron);  rs1485714 (A/G:intron);  rs812965 (A/G:mrna-utr);  rs608981 (G/C:intron);  rs3102826 (C/A:intron);  rs659664 (G/A:intron);  rs684753 (C/G:intron);  rs694462 (G/C:intron);  rs813602 (A/T:intron);  rs1157725 (A/C:intron);  rs974035 (C/G:intron);  rs661793 (C/T:intron);  rs688567 (C/G:intron);  rs2630189 (T/C:intron);  rs192667 (C/G:intron);  rs3047575 (AA/-:intron);  rs972773 (C/T:intron);  rs651680 (C/A:intron);  rs606735 (A/G:intron);  rs1973780 (G/T:intron);  rs629300 (T/A:intron);  rs541960 (T/C:intron);  rs687447 (C/A:intron);  rs604398 (T/C:intron);  rs1352020 (C/G:intron);  rs505780 (C/G:intron);  rs2367084 (C/T:intron);  rs780343 (C/T:intron);  rs1374858 (C/G:intron);  rs2736791 (A/G:intron);  rs643121 (C/T:intron);  rs1349019 (A/C:intron);  rs582381 (A/T:intron);  rs1385811 (A/G:intron);  rs588866 (A/G:intron);  rs669497 (T/C:intron);  rs2630167 (A/G:intron);  rs802771 (A/C:intron);  rs931317 (A/G:intron);  rs584551 (G/A:intron);  rs2034336 (A/T:intron);  rs599589 (C/T:intron);  rs552676 (A/G:intron);  rs2228695 (A/G:intron);  rs2630162 (T/G:intron);  rs1829841 (A/C:intron);  rs1613046 (G/A:intron);  rs2605432 (T/C:intron);  rs2366962 (C/T:intron);  rs608341 (T/C:intron);  rs1111567 (G/T:intron);  rs550738 (C/T:intron);  rs2253211 (C/T:intron);  rs650197 (A/T:intron);  rs521388 (T/C:intron);  rs212029 (C/T:intron);  rs680467 (A/T:intron);  rs3074255 (AGTAAGT/-:mrna-utr);  rs671754 (A/G:intron);  rs2276732 (C/T:intron);  rs2253303 (A/T:intron);  rs615275 (A/G:intron);  rs1719823 (G/T:intron);  rs294450 (G/A:intron);  rs810525 (T/A:intron);  rs673756 (G/C:intron);  rs672759 (C/A:intron);  rs1550925 (C/T:intron);  rs526389 (T/C:intron);  rs622875 (T/C:intron);  rs672802 (A/T:intron);  rs2293211 (A/G:intron);  rs186060 (G/T:intron);  rs695144 (A/G:intron);  rs677264 (G/C:intron);  rs1523115 (C/T:intron);  rs2251216 (T/C:intron);  rs502739 (A/G:mrna-utr);  rs608935 (T/G:intron);  rs2171077 (A/C:intron);  rs526773 (A/G:intron);  rs594055 (G/T:intron);  rs563600 (C/T:intron);  rs1026989 (C/T:intron);  rs679533 (T/G:intron);  rs689364 (A/T:intron);  rs615143 (C/T:intron);  rs2220240 (A/G:intron);  rs2367105 (A/G:intron);  rs583560 (T/G:intron);  rs550626 (T/C:intron);  rs1825630 (A/G:intron);  rs1809540 (G/T:intron);  rs810615 (C/T:intron);  rs599096 (A/C:intron);  rs598616 (A/T:intron);  rs606168 (T/C:intron);  rs176921 (C/G:intron);  rs212012 (C/G:intron);  rs979312 (C/G:mrna-utr);  rs1683343 (T/A:intron);  rs628404 (T/C:intron);  rs1126268 (A/G:intron);  rs1474308 (A/G:intron);  rs502074 (C/G:intron);  rs586011 (T/C:intron);  rs644301 (C/T:intron);  rs683908 (C/A:intron);  rs670885 (A/C:intron);  rs681119 (C/T:intron);  rs492695 (T/C:intron);  rs936823 (G/T:intron);  rs626988 (A/C:intron);  rs675774 (T/C:intron);  rs598164 (A/G:intron);  rs657207 (G/A:intron);  rs2366968 (A/G:intron);  rs606415 (A/G:intron);  rs293602 (C/A:intron);  rs646372 (A/G:intron);  rs608878 (A/T:intron);  rs570366 (C/T:intron);  rs605545 (G/A:intron);  rs169838 (T/C:intron);  rs2166790 (C/G:intron);  rs637820 (G/A:intron);  rs686915 (G/C:intron);  rs492234 (C/G:intron);  rs1485725 (C/T:intron);  rs615356 (G/T:intron);  rs2220227 (C/G:intron);  rs528473 (C/G:intron);  rs680939 (C/G:intron);  rs607731 (C/T:intron);  rs693495 (A/G:intron);  rs669229 (G/A:intron);  rs597224 (G/A:intron);  rs49411 (A/G:intron);  rs809710 (A/G:intron);  rs683809 (T/C:intron);  rs492836 (T/C:intron);  rs1843398 (A/C:intron);  rs994928 (A/G:intron);  rs2200453 (A/C:intron);  rs1079196 (C/T:intron);  rs517711 (C/T:intron);  rs992999 (C/T:intron);  rs525882 (C/G:intron);  rs560357 (G/T:intron);  rs1628506 (T/C:intron);  rs979986 (T/G:intron);  rs598667 (T/C:intron);  rs750793 (C/T:intron);  rs635527 (G/T:intron);  rs632140 (A/C:intron);  rs813608 (C/G:intron);  rs687069 (G/A:intron);  rs582805 (C/A:intron);  rs600427 (C/A:intron);  rs652105 (T/C:intron);  rs192674 (T/G:intron);  rs652508 (C/G:intron);  rs586389 (T/G:intron);  rs1825633 (C/G:intron);  rs670469 (T/C:intron);  rs663259 (G/C:intron);  rs624225 (C/T:intron);  rs517644 (G/A:intron);  rs596938 (T/A:intron);  rs659193 (T/C:intron);  rs901163 (A/T:intron);  rs640115 (T/C:intron);  rs2736814 (G/A:intron);  rs652995 (A/C:intron);  rs655011 (G/C:intron);  rs1970842 (C/G:intron);  rs615501 (C/T:intron);  rs614379 (T/G:intron);  rs642214 (G/A:intron);  rs633798 (A/G:intron);  rs1683366 (A/G:intron);  rs2687895 (T/G:intron);  rs670592 (A/C:intron);  rs177035 (A/G:intron);  rs598508 (G/C:intron);  rs591934 (G/A:intron);  rs629627 (A/T:intron);  rs694089 (A/G:intron);  rs658563 (A/C:intron);  rs643629 (T/C:intron);  rs680884 (G/A:intron);  rs590581 (A/G:intron);  rs688947 (C/T:intron);  rs190890 (G/T:intron);  rs2629877 (T/G:intron);  rs660050 (G/T:intron);  rs610766 (A/G:intron);  rs970883 (T/G:intron);  rs1817587 (C/T:intron);  rs620783 (G/A:intron);  rs2630186 (T/C:intron);  rs814296 (A/C:intron);  rs2101322 (T/C:intron);  rs685970 (T/A:intron);  rs2367086 (A/C:mrna-utr);  rs2366952 (C/G:intron);  rs599459 (A/C:intron);  rs599423 (A/C:intron);  rs809076 (C/G:intron);  rs616503 (C/A:intron);  rs592876 (A/G:intron);  rs689497 (C/T:intron);  rs744192 (C/T:intron);  rs594063 (C/T:intron);  rs612759 (G/C:intron);  rs167159 (T/G:intron);  rs623014 (A/G:intron);  rs1038500 (A/G:intron);  rs2046454 (C/T:intron);  rs188398 (G/A:intron);  rs2605446 (G/C:intron);  rs497767 (T/C:intron);  rs477697 (A/G:intron);  rs639705 (A/C:intron);  rs675411 (T/C:intron);  rs534185 (C/A:intron);  rs1967997 (C/G:intron);  rs687342 (A/G:intron);  rs633638 (A/C:intron);  rs515208 (C/T:intron);  rs585448 (T/C:intron);  rs615542 (C/G:intron);  rs1612985 (G/T:intron);  rs639244 (G/C:intron);  rs623032 (C/A:intron);  rs658725 (C/A:intron);  rs471011 (C/T/A:intron);  rs2086977 (A/T:intron);  rs874238 (C/T:intron);  
EvidenceMethylation in Prostate cancer

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Department of Urology
Universityof California, San Francisco