| Name | fragile histidine triad gene |
| Symbol | FHIT |
| Aliases | FRA3B; AP3Aase; AP3A hydrolase; dinucleosidetriphosphatase; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase |
| Gene Product | - fragile histidine triad gene
|
| Category | - Methylation in Prostate cancer
|
| UniGene | Hs.77252 |
| OMIM | 601153 |
| Locus | 2272 |
| Summary | This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. |
| Gene Ontology | |
| Expression | | EST (81 ESTs, 31 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| brain (1/204) |  | 1/362011 |
| colon (1/853) | | 1/165626 |
| embryo (1/19) | | 1/37976 |
| eye (2/33) | | 3/93836 |
| foreskin (1/4) | | 1/20040 |
| germ cell (1/7) | | 2/57383 |
| kidney (4/86) | | 5/132968 |
| lung (2/312) | | 2/245386 |
| nervous (1/475) | | 2/43438 |
| pancreas (1/33) | | 1/117255 |
| placenta (1/342) | | 1/157762 |
| prostate (1/291) |  | 1/109871 |
| spleen (1/7) | | 1/9511 |
| stomach (1/312) | | 9/129930 |
| testis (1/171) | | 1/117531 |
| uncharacterized tissue (11/1773) | | 49/713325 |
|
| SAGE (2177357 tags, 40 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| brain (9/19) | | 13/617412 |
| colon (1/8) | | 1/57686 |
| eye (1/6) | | 5/53666 |
| liver (1/1) | | 1/66861 |
| mammary gland (6/19) | | 9/322446 |
| ovary (1/10) | | 2/67350 |
| pancreas (2/8) | | 2/81018 |
| prostate (5/13) | | 6/306360 |
| stomach (2/3) | | 2/136465 |
| uncharacterized tissue (6/22) | | 7/339346 |
| vascular (2/3) | | 2/128747 |
|
|
| SNP | rs812427 (G/C:intron); rs637319 (T/C:intron); rs662910 (T/C:intron); rs635904 (G/T:intron); rs510015 (C/A:intron); rs666445 (T/C:intron); rs17493 (A/G:intron); rs1905863 (A/C:intron); rs589792 (C/T:intron); rs1564912 (A/G:intron); rs575614 (C/G:intron); rs167140 (A/G:intron); rs3074239 (CTTAA/-:mrna-utr); rs1666057 (C/T:intron); rs1964583 (C/G:intron); rs1629023 (C/A:intron); rs666083 (C/G:intron); rs529626 (G/T:intron); rs780374 (G/C:intron); rs1021227 (A/T:intron); rs644087 (G/T:intron); rs597790 (G/C:intron); rs3112498 (A/T:intron); rs3100801 (A/G:intron); rs673870 (C/T:intron); rs2077774 (A/C:mrna-utr); rs1385710 (A/G:mrna-utr); rs650905 (G/A:intron); rs780935 (T/G:intron); rs1666092 (C/A:intron); rs587775 (C/T:intron); rs562516 (T/C:intron); rs172455 (T/A:intron); rs1872494 (G/T:intron); rs503665 (C/T:mrna-utr); rs3075168 (-/CA:intron); rs1960248 (A/C:intron); rs3047601 (AA/-:intron); rs1813201 (C/T:intron); rs616604 (C/G:intron); rs615964 (G/C:intron); rs493783 (T/A:intron); rs1879996 (A/G:intron); rs575388 (A/G:intron); rs1630608 (T/A:intron); rs2736802 (C/T:intron); rs190899 (T/C:intron); rs678729 (T/G:intron); rs677703 (G/A:intron); rs608582 (A/G:intron); rs2361333 (A/G:intron); rs481165 (C/G:intron); rs3112500 (T/G:intron); rs621666 (C/T:intron); rs583363 (C/T:intron); rs671920 (A/G:intron); rs482814 (C/G:intron); rs609891 (T/C:intron); rs659036 (T/C:intron); rs1797563 (A/T:intron); rs602197 (C/T:intron); rs1456157 (C/T:intron); rs1319341 (T/G:intron); rs1159236 (C/G:intron); rs475675 (G/A:intron); rs184149 (T/G:intron); rs510794 (T/C:intron); rs923141 (C/T:intron); rs678205 (A/G:intron); rs672225 (T/G:intron); rs592763 (A/C:intron); rs582313 (A/C:intron); rs684584 (G/A:intron); rs599542 (C/G:intron); rs565226 (A/C:intron); rs678981 (A/G:intron); rs1983425 (A/T:intron); rs720000 (A/G:mrna-utr); rs660097 (A/C:intron); rs1485714 (A/G:intron); rs812965 (A/G:mrna-utr); rs608981 (G/C:intron); rs3102826 (C/A:intron); rs659664 (G/A:intron); rs684753 (C/G:intron); rs694462 (G/C:intron); rs813602 (A/T:intron); rs1157725 (A/C:intron); rs974035 (C/G:intron); rs661793 (C/T:intron); rs688567 (C/G:intron); rs2630189 (T/C:intron); rs192667 (C/G:intron); rs3047575 (AA/-:intron); rs972773 (C/T:intron); rs651680 (C/A:intron); rs606735 (A/G:intron); rs1973780 (G/T:intron); rs629300 (T/A:intron); rs541960 (T/C:intron); rs687447 (C/A:intron); rs604398 (T/C:intron); rs1352020 (C/G:intron); rs505780 (C/G:intron); rs2367084 (C/T:intron); rs780343 (C/T:intron); rs1374858 (C/G:intron); rs2736791 (A/G:intron); rs643121 (C/T:intron); rs1349019 (A/C:intron); rs582381 (A/T:intron); rs1385811 (A/G:intron); rs588866 (A/G:intron); rs669497 (T/C:intron); rs2630167 (A/G:intron); rs802771 (A/C:intron); rs931317 (A/G:intron); rs584551 (G/A:intron); rs2034336 (A/T:intron); rs599589 (C/T:intron); rs552676 (A/G:intron); rs2228695 (A/G:intron); rs2630162 (T/G:intron); rs1829841 (A/C:intron); rs1613046 (G/A:intron); rs2605432 (T/C:intron); rs2366962 (C/T:intron); rs608341 (T/C:intron); rs1111567 (G/T:intron); rs550738 (C/T:intron); rs2253211 (C/T:intron); rs650197 (A/T:intron); rs521388 (T/C:intron); rs212029 (C/T:intron); rs680467 (A/T:intron); rs3074255 (AGTAAGT/-:mrna-utr); rs671754 (A/G:intron); rs2276732 (C/T:intron); rs2253303 (A/T:intron); rs615275 (A/G:intron); rs1719823 (G/T:intron); rs294450 (G/A:intron); rs810525 (T/A:intron); rs673756 (G/C:intron); rs672759 (C/A:intron); rs1550925 (C/T:intron); rs526389 (T/C:intron); rs622875 (T/C:intron); rs672802 (A/T:intron); rs2293211 (A/G:intron); rs186060 (G/T:intron); rs695144 (A/G:intron); rs677264 (G/C:intron); rs1523115 (C/T:intron); rs2251216 (T/C:intron); rs502739 (A/G:mrna-utr); rs608935 (T/G:intron); rs2171077 (A/C:intron); rs526773 (A/G:intron); rs594055 (G/T:intron); rs563600 (C/T:intron); rs1026989 (C/T:intron); rs679533 (T/G:intron); rs689364 (A/T:intron); rs615143 (C/T:intron); rs2220240 (A/G:intron); rs2367105 (A/G:intron); rs583560 (T/G:intron); rs550626 (T/C:intron); rs1825630 (A/G:intron); rs1809540 (G/T:intron); rs810615 (C/T:intron); rs599096 (A/C:intron); rs598616 (A/T:intron); rs606168 (T/C:intron); rs176921 (C/G:intron); rs212012 (C/G:intron); rs979312 (C/G:mrna-utr); rs1683343 (T/A:intron); rs628404 (T/C:intron); rs1126268 (A/G:intron); rs1474308 (A/G:intron); rs502074 (C/G:intron); rs586011 (T/C:intron); rs644301 (C/T:intron); rs683908 (C/A:intron); rs670885 (A/C:intron); rs681119 (C/T:intron); rs492695 (T/C:intron); rs936823 (G/T:intron); rs626988 (A/C:intron); rs675774 (T/C:intron); rs598164 (A/G:intron); rs657207 (G/A:intron); rs2366968 (A/G:intron); rs606415 (A/G:intron); rs293602 (C/A:intron); rs646372 (A/G:intron); rs608878 (A/T:intron); rs570366 (C/T:intron); rs605545 (G/A:intron); rs169838 (T/C:intron); rs2166790 (C/G:intron); rs637820 (G/A:intron); rs686915 (G/C:intron); rs492234 (C/G:intron); rs1485725 (C/T:intron); rs615356 (G/T:intron); rs2220227 (C/G:intron); rs528473 (C/G:intron); rs680939 (C/G:intron); rs607731 (C/T:intron); rs693495 (A/G:intron); rs669229 (G/A:intron); rs597224 (G/A:intron); rs49411 (A/G:intron); rs809710 (A/G:intron); rs683809 (T/C:intron); rs492836 (T/C:intron); rs1843398 (A/C:intron); rs994928 (A/G:intron); rs2200453 (A/C:intron); rs1079196 (C/T:intron); rs517711 (C/T:intron); rs992999 (C/T:intron); rs525882 (C/G:intron); rs560357 (G/T:intron); rs1628506 (T/C:intron); rs979986 (T/G:intron); rs598667 (T/C:intron); rs750793 (C/T:intron); rs635527 (G/T:intron); rs632140 (A/C:intron); rs813608 (C/G:intron); rs687069 (G/A:intron); rs582805 (C/A:intron); rs600427 (C/A:intron); rs652105 (T/C:intron); rs192674 (T/G:intron); rs652508 (C/G:intron); rs586389 (T/G:intron); rs1825633 (C/G:intron); rs670469 (T/C:intron); rs663259 (G/C:intron); rs624225 (C/T:intron); rs517644 (G/A:intron); rs596938 (T/A:intron); rs659193 (T/C:intron); rs901163 (A/T:intron); rs640115 (T/C:intron); rs2736814 (G/A:intron); rs652995 (A/C:intron); rs655011 (G/C:intron); rs1970842 (C/G:intron); rs615501 (C/T:intron); rs614379 (T/G:intron); rs642214 (G/A:intron); rs633798 (A/G:intron); rs1683366 (A/G:intron); rs2687895 (T/G:intron); rs670592 (A/C:intron); rs177035 (A/G:intron); rs598508 (G/C:intron); rs591934 (G/A:intron); rs629627 (A/T:intron); rs694089 (A/G:intron); rs658563 (A/C:intron); rs643629 (T/C:intron); rs680884 (G/A:intron); rs590581 (A/G:intron); rs688947 (C/T:intron); rs190890 (G/T:intron); rs2629877 (T/G:intron); rs660050 (G/T:intron); rs610766 (A/G:intron); rs970883 (T/G:intron); rs1817587 (C/T:intron); rs620783 (G/A:intron); rs2630186 (T/C:intron); rs814296 (A/C:intron); rs2101322 (T/C:intron); rs685970 (T/A:intron); rs2367086 (A/C:mrna-utr); rs2366952 (C/G:intron); rs599459 (A/C:intron); rs599423 (A/C:intron); rs809076 (C/G:intron); rs616503 (C/A:intron); rs592876 (A/G:intron); rs689497 (C/T:intron); rs744192 (C/T:intron); rs594063 (C/T:intron); rs612759 (G/C:intron); rs167159 (T/G:intron); rs623014 (A/G:intron); rs1038500 (A/G:intron); rs2046454 (C/T:intron); rs188398 (G/A:intron); rs2605446 (G/C:intron); rs497767 (T/C:intron); rs477697 (A/G:intron); rs639705 (A/C:intron); rs675411 (T/C:intron); rs534185 (C/A:intron); rs1967997 (C/G:intron); rs687342 (A/G:intron); rs633638 (A/C:intron); rs515208 (C/T:intron); rs585448 (T/C:intron); rs615542 (C/G:intron); rs1612985 (G/T:intron); rs639244 (G/C:intron); rs623032 (C/A:intron); rs658725 (C/A:intron); rs471011 (C/T/A:intron); rs2086977 (A/T:intron); rs874238 (C/T:intron); |
| Evidence | Methylation in Prostate cancer
|
