Human Prostate Gene DataBase

Name cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6
Symbol CYP2D6
Aliases CPD6; CYP2D; CYP2D@; P450C2D; P450-DB1; microsomal monooxygenase; xenobiotic monooxygenase; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase
Gene Product
  • cytochrome P450, subfamily IID, polypeptide 6
  • Mutation in Prostate cancer
SummaryThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1.
Gene Ontology
EST (44 ESTs, 12 libraries)
Tissue ? Frequency ? Count ?
brain (1/204)0.063 1/362011
colon (1/853)1.000 1/165626
embryo (1/19)0.002 1/37976
eye (1/33)0.005 2/93836
germ cell (1/7)0.004 1/57383
liver (2/38)0.015 7/46472
prostate (1/291)0.015 3/109871
skin (1/31)0.005 1/100815
uncharacterized tissue (3/1773)0.071 27/713325
SAGE (1845611 tags, 36 libraries)
Tissue ? Frequency ? Count ?
brain (4/19)0.107 5/299252
colon (5/8)0.239 12/342592
eye (1/6)0.072 1/53666
kidney (1/2)0.369 2/41857
liver (1/1)1.000 5/133722
mammary gland (1/19)0.244 1/63227
ovary (2/10)0.273 3/128677
pancreas (2/8)0.419 2/73712
prostate (3/13)0.172 4/256738
stomach (1/3)0.078 1/66032
uncharacterized tissue (9/22)0.289 10/386136
SNPrs2856955 (A/C:mrna-utr);  rs2743454 (G/A:locus-region);  rs1800716 (T/C:coding-nonsyn);  rs1467871 (A/G:locus-region);  rs1058174 (C/T:mrna-utr);  rs1058164 (T/C:coding-nonsyn);  rs915947 (C/T:intron);  rs3021076 (C/G:coding-nonsyn);  rs762554 (G/T:intron);  rs2103555 (G/C:coding-nonsyn);  rs2070906 (G/A:coding-nonsyn);  rs1966154 (A/C:mrna-utr);  rs2267444 (A/G:coding-nonsyn);  rs3020730 (C/A:intron);  rs1974456 (A/G:coding-nonsyn);  rs2899353 (A/C:intron);  rs2982052 (G/C:locus-region);  rs2092118 (A/G:mrna-utr);  rs3045543 (TC/-:intron);  rs769256 (T/G:mrna-utr);  rs2004511 (C/T:intron);  rs2854740 (C/G:intron);  rs2860372 (C/T:intron);  rs2272812 (G/T:intron);  rs2413675 (C/T:mrna-utr);  
EvidenceMutation in Prostate cancer

© 2002, PGDB, All Rights Reserved.
Department of Urology
Universityof California, San Francisco