Human

Human Prostate Gene DataBase
Name cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Symbol CDKN1A
Aliases P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; DNA synthesis inhibitor; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6
Gene Product
  • cyclin-dependent kinase inhibitor 1A
Category
  • Methylation in Prostate cancer
  • Mutation in Prostate cancer
  • Polymorphism in Prostate cancer
UniGeneHs.179665
OMIM116899
Locus1026
SummaryThis gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
Gene Ontology
Expression
EST (747 ESTs, 232 libraries)
Tissue ? Frequency ? Count ?
adipose (1/10)0.041 2/2445
adrenal gland (1/15)0.003 1/17521
blood (4/27)0.032 5/40686
bone (2/13)0.022 9/26211
brain (16/204)0.007 50/362011
cartilage (2/5)0.022 5/11018
cervix (2/7)0.007 13/28115
colon (17/853)0.007 37/165626
ear (1/2)0.006 4/12660
embryo (2/19)0.001 2/37976
esophagus (1/6)0.007 1/3022
eye (5/33)0.012 30/93836
foreskin (1/4)0.015 15/20040
germ cell (4/7)0.003 6/57383
head and neck (9/990)0.408 9/79796
heart (2/22)0.513 13/55494
intestine (2/4)0.007 5/11528
kidney (8/86)0.044 21/132968
liver (3/38)0.003 10/46472
lung (30/312)0.003 140/245386
muscle (4/21)0.031 14/71297
nervous (4/475)1.000 7/43438
ovary (3/144)0.005 6/81880
pancreas (9/33)0.020 44/117255
parathyroid (1/4)0.002 2/19377
placenta (11/342)0.129 35/157762
prostate (5/291)0.003 9/109871
skin (7/31)0.033 34/100815
stomach (14/312)0.097 61/129930
testis (4/171)0.001 14/117531
thymus (1/17)0.025 1/5021
thyroid (2/24)0.045 2/6853
uncharacterized tissue (44/1773)0.006 107/713325
uterus (9/212)0.002 32/155110
SAGE (1185809 tags, 21 libraries)
Tissue ? Frequency ? Count ?
brain (5/19)0.133 5/293575
colon (1/8)0.062 1/52094
eye (2/6)0.183 4/263357
foreskin (1/2)1.000 1/9759
mammary gland (3/19)0.098 3/184114
pancreas (1/8)0.300 1/32512
prostate (1/13)0.142 1/68626
stomach (1/3)0.092 2/70433
uncharacterized tissue (4/22)0.129 4/211339
SNPrs762623 (A/C:locus-region);  rs2894408 (C/T:mrna-utr);  rs2395655 (A/G:locus-region);  rs733590 (C/T:locus-region);  rs730506 (C/G:locus-region);  
EvidenceMethylation in Prostate cancer Mutation in Prostate cancer Polymorphism in Prostate cancer
© 2002, PGDB, All Rights Reserved.
Department of Urology
Universityof California, San Francisco