| Name | caveolin 1, caveolae protein, 22kD |
| Symbol | CAV1 |
| Aliases | CAV; VIP21; caveolae protein, 22-kD; caveolin 1, beta isoform; caveolin 1, alpha isoform; caveolin 1 caveolae protein, 22kD |
| Gene Product | |
| Category | - Methylation in Prostate cancer
|
| UniGene | Hs.74034 |
| OMIM | 601047 |
| Locus | 857 |
| Summary | The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. |
| Gene Ontology | |
| Expression | | EST (684 ESTs, 202 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| adipose (2/10) |  | 8/2445 |
| blood (3/27) | | 3/40686 |
| bone (4/13) | | 28/26211 |
| bone marrow (3/263) | | 4/38555 |
| brain (10/204) | | 45/362011 |
| cartilage (1/5) | | 1/11018 |
| colon (5/853) | | 9/165626 |
| embryo (4/19) | | 13/37976 |
| eye (5/33) | | 11/93836 |
| foreskin (1/4) | | 21/20040 |
| germ cell (2/7) | | 3/57383 |
| head and neck (7/990) | | 9/79796 |
| heart (6/22) | | 37/55494 |
| kidney (7/86) | | 27/132968 |
| liver (1/38) | | 14/46472 |
| lung (25/312) | | 111/245386 |
| mammary gland (1/1) | | 3/2313 |
| muscle (3/21) | | 4/71297 |
| nervous (2/475) | | 2/43438 |
| ovary (4/144) | | 4/81880 |
| pancreas (7/33) | | 26/117255 |
| placenta (14/342) | | 54/157762 |
| prostate (9/291) |  | 16/109871 |
| skin (7/31) | | 17/100815 |
| stomach (6/312) | | 20/129930 |
| testis (3/171) | | 7/117531 |
| thymus (1/17) | | 1/5021 |
| thyroid (4/24) | | 8/6853 |
| umbilical cord (1/3) | | 4/6185 |
| uncharacterized tissue (45/1773) | | 132/713325 |
| uterus (8/212) | | 41/155110 |
|
| SAGE (27333362 tags, 525 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/1) | | 1/48523 |
| brain (18/19) | | 365/6398147 |
| cerebellum (1/1) | | 1/51280 |
| colon (8/8) | | 57/1576123 |
| eye (6/6) | | 70/1937385 |
| foreskin (2/2) | | 15/67527 |
| heart (1/1) | | 61/674856 |
| kidney (2/2) | | 6/241363 |
| liver (1/1) | | 6/200583 |
| lung (1/1) | | 121/624001 |
| mammary gland (15/19) | | 184/3406029 |
| muscle (2/2) | | 6/323162 |
| ovary (9/10) | | 98/1467164 |
| pancreas (8/8) | | 61/1091665 |
| prostate (12/13) | | 109/2019198 |
| skin (7/7) | | 30/307536 |
| stomach (3/3) | | 19/707627 |
| uncharacterized tissue (20/22) | | 190/4376262 |
| vascular (3/3) | | 455/1814931 |
|
|
| SNP | rs1997571 (A/C:intron); rs2535213 (C/T:intron); rs1476833 (G/T:intron); rs1049314 (C/A:mrna-utr); rs2302388 (A/G:intron); rs1049334 (C/T:mrna-utr); rs926198 (A/T:intron); rs6867 (A/G:mrna-utr); rs917664 (A/T:intron); rs2052105 (C/T:intron); rs2109516 (C/G:intron); rs3030806 (-/TTTTT:intron); rs959173 (C/T:intron); rs729949 (A/G:intron); rs976739 (T/G:intron); rs1022436 (C/G:intron); rs2215448 (A/G:locus-region); rs1049375 (T/G:mrna-utr); rs2742125 (C/T:intron); rs2402082 (A/T:locus-region); rs8713 (A/C:mrna-utr); rs9920 (T/C:mrna-utr); rs1543293 (C/G:intron); rs1474510 (A/G:intron); |
| Evidence | Methylation in Prostate cancer
|
