Human

Human Prostate Gene DataBase
Name cadherin 1, type 1, E-cadherin (epithelial)
Symbol CDH1
Aliases UVO; CDHE; ECAD; LCAM; Arc-1; uvomorulin; cell-CAM 120/80; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial
Gene Product
  • cadherin 1, type 1 preproprotein
Category
  • Gross deletion in Prostate cancer
  • Methylation in Prostate cancer
  • Mutation in Prostate cancer
  • Polymorphism in Prostate cancer
UniGeneHs.194657
OMIM192090
Locus999
SummaryThis gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
Gene Ontology
Expression
EST (496 ESTs, 227 libraries)
Tissue ? Frequency ? Count ?
b cells (1/1)0.002 1/16734
blood (1/27)0.025 3/40686
bone marrow (1/263)0.005 1/38555
brain (3/204)0.004 4/362011
colon (33/853)0.182 64/165626
ear (1/2)0.011 4/12660
embryo (1/19)0.013 2/37976
esophagus (1/6)0.025 2/3022
foreskin (1/4)0.018 10/20040
gall (1/3)0.047 1/2502
germ cell (2/7)0.009 3/57383
head and neck (24/990)1.000 38/79796
heart (2/22)0.003 3/55494
intestine (1/4)0.081 1/11528
kidney (8/86)0.212 11/132968
liver (3/38)0.002 3/46472
lung (15/312)0.218 25/245386
muscle (1/21)0.006 2/71297
nervous (1/475)0.064 2/43438
ovary (4/144)0.016 4/81880
pancreas (6/33)0.010 14/117255
parathyroid (1/4)0.015 8/19377
placenta (8/342)0.006 33/157762
prostate (5/291)0.010 8/109871
skin (5/31)0.002 7/100815
spleen (1/7)0.015 2/9511
stomach (12/312)0.024 48/129930
testis (1/171)0.001 1/117531
thymus (1/17)0.044 1/5021
thyroid (1/24)0.077 4/6853
uncharacterized tissue (52/1773)0.124 103/713325
uterus (18/212)0.004 39/155110
SAGE (18258534 tags, 359 libraries)
Tissue ? Frequency ? Count ?
blood (1/1)0.056 1/48523
brain (17/19)0.133 58/2908545
cerebellum (1/1)0.186 5/102560
colon (8/8)1.000 211/2356695
eye (6/6)0.272 31/1464242
heart (1/1)0.194 6/253071
kidney (2/2)0.213 8/138091
liver (1/1)0.082 3/66861
lung (1/1)0.311 13/534858
mammary gland (18/19)0.653 253/2355591
muscle (1/2)0.101 2/107750
ovary (8/10)0.289 36/729570
pancreas (8/8)0.642 87/1067335
prostate (12/13)0.525 132/2426250
skin (6/7)0.292 9/100163
stomach (3/3)0.693 70/848493
uncharacterized tissue (21/22)0.440 122/2253112
vascular (3/3)0.118 9/496824
SNPrs2276327 (G/C:coding-nonsyn);  rs2098728 (A/G:intron);  rs2012923 (C/T:intron);  rs1981870 (C/T:intron);  rs2161664 (C/T:intron);  rs1801552 (C/T:coding-nonsyn);  rs1078621 (C/T:intron);  rs2961 (A/G:intron);  rs1968260 (C/T:intron);  rs1812452 (C/G:intron);  rs2862231 (C/T:intron);  rs2059254 (C/T:intron);  rs3074434 (-/AAAAAA:intron);  rs1075384 (C/T:intron);  rs1116485 (C/T:intron);  rs2010724 (A/G:intron);  rs1075959 (C/T:intron);  rs13689 (T/C:mrna-utr);  rs1801023 (C/T:mrna-utr);  rs1138533 (A/G:mrna-utr);  rs2229044 (C/T:coding-nonsyn);  rs1862748 (A/G:intron);  rs1125557 (A/G:intron);  rs16260 (C/A:locus-region);  rs1974873 (A/T:intron);  rs2113199 (G/A:intron);  rs1559366 (A/G:intron);  rs2011779 (C/T:intron);  rs2902185 (A/G:intron);  
EvidenceGross deletion in Prostate cancer Methylation in Prostate cancer Mutation in Prostate cancer Polymorphism in Prostate cancer
© 2002, PGDB, All Rights Reserved.
Department of Urology
Universityof California, San Francisco