Human

Human Prostate Gene DataBase

Name membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
Symbol MME
Aliases CD10; CALLA; NEP; neprilysin
Gene Product
  • membrane metallo-endopeptidase
Category
  • Methylation in Prostate cancer
UniGeneHs.1298
OMIM120520
Locus4311
SummaryCommon acute lymphocytic leukemia antigen is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). It is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. CALLA is not restricted to leukemic cells, however, and is found on a variety of normal tissues. CALLA is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The amino acid sequence deduced from the cDNA sequence is identical to that of human membrane-associated neutral endopeptidase, also known as enkephalinase. NEP cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. The CALLA gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb which is not rearranged in malignancies expressing cell surface CALLA. The CALLA gene spans more than 80 kb and is composed of 24 exons. The 5' untranslated region of CALLA is alternatively spliced, resulting in four separate mRNA transcripts. The coding region initiates in exon 3 and is not affected by alternative splicing. Exons 1, 1bis, 2a and 2b are each spliced to exon 3 to form the four transcript variants.
Gene Ontology
Expression
EST (262 ESTs, 78 libraries)
Tissue ? Frequency ? Count ?
adipose (1/10)0.168 1/2445
adrenal gland (2/15)0.069 8/17521
b cells (1/1)0.020 2/16734
bone (2/13)0.094 4/26211
brain (1/204)0.054 1/362011
colon (3/853)0.037 9/165626
ear (1/2)0.040 3/12660
embryo (1/19)0.014 2/37976
germ cell (1/7)0.018 1/57383
head and neck (1/990)0.497 2/79796
heart (1/22)0.048 10/55494
intestine (1/4)0.382 1/11528
kidney (7/86)1.000 69/132968
liver (1/38)0.103 5/46472
lung (3/312)0.015 5/245386
muscle (3/21)0.046 5/71297
oral cavity (1/18)0.060 15/44567
ovary (2/144)0.164 2/81880
placenta (6/342)0.037 16/157762
prostate (4/291)0.069 7/109871
skin (3/31)0.015 7/100815
testis (2/171)0.009 3/117531
uncharacterized tissue (26/1773)0.034 75/713325
uterus (4/212)0.030 9/155110
SAGE (15102800 tags, 281 libraries)
Tissue ? Frequency ? Count ?
blood (1/1)0.053 2/97046
brain (19/19)0.142 80/3198337
cerebellum (1/1)0.070 2/102560
colon (5/8)0.086 17/632044
eye (4/6)0.167 23/1022566
foreskin (2/2)1.000 8/57768
heart (1/1)0.151 6/253071
kidney (2/2)0.131 5/138091
liver (1/1)0.107 4/200583
lung (1/1)0.217 10/713144
mammary gland (15/19)0.124 33/1112752
muscle (2/2)0.142 7/161603
ovary (7/10)0.222 26/591755
pancreas (8/8)0.164 19/560398
prostate (10/13)0.565 130/3389866
skin (3/7)0.182 5/89066
stomach (2/3)0.067 6/206898
uncharacterized tissue (17/22)0.178 70/2306932
vascular (2/3)0.133 5/268320
SNPrs1485239 (G/T:intron);  rs1299661 (A/G:intron);  rs2016846 (A/G:intron);  rs1836912 (A/G:intron);  rs1807003 (C/G:intron);  rs1062487 (G/C:coding-nonsyn);  rs2196521 (C/T:intron);  rs12765 (A/G:mrna-utr);  rs1370031 (A/G:intron);  rs701109 (A/G:mrna-utr);  rs1126608 (C/G:coding-nonsyn);  rs2304504 (C/T:intron);  rs2011753 (A/G:intron);  rs968628 (C/T:intron);  rs989692 (C/T:mrna-utr);  rs6665 (G/T:mrna-utr);  rs1025192 (C/T:intron);  rs1385479 (A/G:intron);  rs1816558 (C/T:intron);  rs1812652 (C/T:intron);  rs2007329 (A/G:intron);  rs1280064 (T/G:intron);  rs12176 (T/A:mrna-utr);  rs1042290 (C/G:coding-nonsyn);  rs1042301 (A/G:mrna-utr);  rs2164555 (A/G:intron);  rs1803235 (A/T:mrna-utr);  rs2118073 (G/A:mrna-utr);  rs1436630 (A/G:intron);  
EvidenceMethylation in Prostate cancer

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Department of Urology
Universityof California, San Francisco