| Name | tumor necrosis factor (TNF superfamily, member 2) |
| Symbol | TNF |
| Aliases | DIF; TNFA; TNFSF2; tumor necrosis factor; tumor necrosis factor (cachectin); tumor necrosis factor, alpha (cachectin) |
| Gene Product | - tumor necrosis factor (cachectin)
|
| Category | - Polymorphism in Prostatitis
|
| UniGene | Hs.241570 |
| OMIM | 191160 |
| Locus | 7124 |
| Summary | TNF plays a central role in the pathophysiology of sepsis. High levels of TNF alpha correlates with increased disease severity in severe bacterial infection and malaria TNF alpha signaling may lead to activation of NF kappa B and induction of apoptosis. |
| Gene Ontology | |
| Expression | | EST (46 ESTs, 21 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/27) |  | 1/40686 |
| brain (1/204) | | 1/362011 |
| colon (1/853) | | 1/165626 |
| germ cell (1/7) | | 1/57383 |
| heart (1/22) | | 1/55494 |
| lung (1/312) | | 1/245386 |
| oral cavity (1/18) | | 4/44567 |
| ovary (1/144) | | 1/81880 |
| placenta (1/342) | | 4/157762 |
| prostate (1/291) |  | 1/109871 |
| stomach (1/312) | | 6/129930 |
| testis (1/171) | | 1/117531 |
| uncharacterized tissue (9/1773) | | 23/713325 |
|
| SAGE (7224121 tags, 158 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/1) | | 5/48523 |
| brain (19/19) | | 298/1656477 |
| cerebellum (1/1) | | 27/51280 |
| colon (8/8) | | 235/723557 |
| eye (5/6) | | 90/286744 |
| foreskin (2/2) | | 15/19256 |
| heart (1/1) | | 6/84357 |
| kidney (2/2) | | 18/73935 |
| liver (1/1) | | 3/66861 |
| lung (1/1) | | 8/178286 |
| mammary gland (18/19) | | 186/820217 |
| muscle (2/2) | | 11/215456 |
| ovary (9/10) | | 78/383685 |
| pancreas (8/8) | | 156/387243 |
| prostate (13/13) | | 180/843974 |
| skin (7/7) | | 20/103054 |
| stomach (3/3) | | 22/227799 |
| uncharacterized tissue (21/22) | | 227/866666 |
| vascular (3/3) | | 43/186751 |
|
|
| SNP | rs3093725 (-/G:locus-region); rs2507961 (C/T:locus-region); rs1800610 (T/C:locus-region); rs361525 (G/A:locus-region); rs3093547 (T/C:locus-region); rs1799964 (C/T:locus-region); rs3091256 (A/G:locus-region); rs3093544 (C/G:locus-region); rs2736195 (G/T:locus-region); rs1799724 (T/C:locus-region); rs1800630 (C/A:locus-region); rs2515924 (G/A:locus-region); rs2857711 (G/T:locus-region); rs3093659 (C/G:locus-region); rs2228088 (G/T:locus-region); rs673 (A/G:locus-region); |
| Evidence | Polymorphism in Prostatitis
|
