| Name | core promoter element binding protein |
| Symbol | COPEB |
| Aliases | GBF; ZF9; BCD1; CPBP; KLF6; B cell-derived 1; B-cell derived 1 |
| Gene Product | - core promoter element binding protein
|
| Category | - Mutation in Prostate cancer
|
| UniGene | Hs.285313 |
| OMIM | 602053 |
| Locus | 1316 |
| Summary | This gene encodes a nuclear protein, core promoter element binding protein. This protein has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. This protein is expressed in several tissues, with the highest levels in the placenta. It is a trancriptional activator, capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein gene and possibly other TATA box-less genes. |
| Expression | | EST (343 ESTs, 154 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (3/27) |  | 15/40686 |
| bone (2/13) | | 2/26211 |
| bone marrow (2/263) | | 13/38555 |
| brain (8/204) | | 18/362011 |
| colon (16/853) | | 28/165626 |
| ear (1/2) | | 2/12660 |
| embryo (3/19) | | 12/37976 |
| esophagus (1/6) | | 2/3022 |
| eye (7/33) | | 30/93836 |
| germ cell (1/7) | | 1/57383 |
| head and neck (3/990) | | 3/79796 |
| heart (1/22) | | 1/55494 |
| kidney (5/86) | | 11/132968 |
| liver (3/38) | | 4/46472 |
| lung (18/312) | | 40/245386 |
| mammary gland (1/1) | | 5/2313 |
| muscle (1/21) | | 1/71297 |
| nervous (2/475) | | 3/43438 |
| oral cavity (1/18) | | 2/44567 |
| ovary (5/144) | | 10/81880 |
| pancreas (9/33) | | 19/117255 |
| placenta (4/342) | | 6/157762 |
| prostate (4/291) |  | 7/109871 |
| skin (4/31) | | 12/100815 |
| stomach (6/312) | | 21/129930 |
| testis (3/171) | | 4/117531 |
| thymus (1/17) | | 1/5021 |
| uncharacterized tissue (29/1773) | | 45/713325 |
| uterus (8/212) | | 23/155110 |
|
| SAGE (10208860 tags, 196 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/1) | | 10/194092 |
| brain (17/19) | | 49/2039176 |
| cerebellum (1/1) | | 4/205120 |
| colon (7/8) | | 48/1110398 |
| eye (5/6) | | 21/1115906 |
| foreskin (1/2) | | 1/9497 |
| heart (1/1) | | 4/253071 |
| kidney (1/2) | | 6/41857 |
| liver (1/1) | | 3/133722 |
| lung (1/1) | | 9/178286 |
| mammary gland (13/19) | | 70/1365890 |
| muscle (2/2) | | 5/269309 |
| ovary (7/10) | | 28/602109 |
| pancreas (7/8) | | 28/429555 |
| prostate (8/13) | | 19/455277 |
| skin (3/7) | | 5/39547 |
| stomach (2/3) | | 8/202497 |
| uncharacterized tissue (17/22) | | 71/1242628 |
| vascular (3/3) | | 19/320923 |
|
|
| SNP | rs1050046 (C/A:locus-region); rs17658 (G/A:locus-region); rs1062673 (C/G:locus-region); rs1043003 (A/G:locus-region); rs7634 (T/A:locus-region); |
| Evidence | Mutation in Prostate cancer
|
