| Name | mitogen-activated protein kinase kinase 4 |
| Symbol | MAP2K4 |
| Aliases | MEK4; MKK4; JNKK1; SERK1; MAPKK4; PRKMK4 |
| Gene Product | - mitogen-activated protein kinase kinase 4
|
| Category | - Gross deletion in Prostate cancer
|
| UniGene | Hs.75217 |
| OMIM | 601335 |
| Locus | 6416 |
| Summary | SAPK/Erk-kinase; dual specificity protein kinase that activates JNKs and Mpk2 |
| Gene Ontology | |
| Expression | | EST (155 ESTs, 84 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| adrenal gland (1/15) |  | 1/17521 |
| b cells (1/1) | | 5/16734 |
| bone (1/13) | | 1/26211 |
| bone marrow (1/263) | | 2/38555 |
| brain (12/204) | | 33/362011 |
| colon (5/853) | | 6/165626 |
| embryo (2/19) | | 4/37976 |
| eye (2/33) | | 3/93836 |
| head and neck (2/990) | | 3/79796 |
| heart (1/22) | | 2/55494 |
| intestine (1/4) | | 1/11528 |
| kidney (4/86) | | 6/132968 |
| lung (1/312) | | 1/245386 |
| muscle (1/21) | | 1/71297 |
| oral cavity (1/18) | | 5/44567 |
| ovary (3/144) | | 5/81880 |
| pancreas (1/33) | | 1/117255 |
| parathyroid (1/4) | | 1/19377 |
| placenta (6/342) | | 9/157762 |
| prostate (3/291) |  | 3/109871 |
| skin (1/31) | | 2/100815 |
| stomach (3/312) | | 6/129930 |
| testis (5/171) | | 6/117531 |
| uncharacterized tissue (19/1773) | | 40/713325 |
| uterus (5/212) | | 7/155110 |
|
| SAGE (10625503 tags, 207 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/1) | | 11/48523 |
| brain (18/19) | | 100/2360309 |
| cerebellum (1/1) | | 7/51280 |
| colon (7/8) | | 18/680973 |
| eye (5/6) | | 19/848574 |
| heart (1/1) | | 6/168714 |
| kidney (1/2) | | 3/96234 |
| liver (1/1) | | 5/200583 |
| lung (1/1) | | 9/267429 |
| mammary gland (15/19) | | 54/1591317 |
| muscle (2/2) | | 12/269331 |
| ovary (8/10) | | 18/341029 |
| pancreas (7/8) | | 21/392814 |
| prostate (12/13) | | 49/1117732 |
| skin (5/7) | | 10/102731 |
| stomach (3/3) | | 7/323534 |
| uncharacterized tissue (17/22) | | 52/1390894 |
| vascular (3/3) | | 10/373502 |
|
|
| SNP | rs2190853 (C/G:locus-region); rs1049438 (G/A:mrna-utr); rs976244 (C/T:intron); rs3042416 (AAAA/-:intron); rs2322123 (A/G:intron); rs2159011 (T/C:intron); rs1468502 (C/G:intron); rs970256 (T/G:intron); rs757594 (C/T:intron); rs2010008 (C/T:intron); rs2108697 (G/A:intron); rs2159140 (G/C:intron); rs966342 (A/G:intron); rs929441 (C/G:intron); rs2041152 (C/G:intron); rs1034870 (A/C:intron); rs1870583 (C/T:intron); rs1981628 (G/T:intron); rs2322283 (A/G:intron); rs1017743 (A/T:intron); rs1787 (G/C:intron); rs2013214 (A/G:intron); |
| Evidence | Gross deletion in Prostate cancer
|
