Human

Human Prostate Gene DataBase
Name phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
Symbol PTEN
Aliases BZS; MHAM; TEP1; MMAC1; Bannayan-Zonana syndrome; multiple hamartoma (Cowden syndrome)
Gene Product
  • phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
Category
  • Gross deletion in Prostate cancer
  • Mutation in Prostate cancer
  • Polymorphism in Benign prostate hyperplasia
  • Polymorphism in Prostate cancer
UniGeneHs.10712 Hs.356062
OMIM601728
Locus5728
SummaryDual specificity phosphatase (tensin homolog); putative tumor suppressor
Gene Ontology
Expression
EST (276 ESTs, 102 libraries)
Tissue ? Frequency ? Count ?
blood (1/27)0.003 1/40686
bone (1/13)0.008 1/26211
brain (5/204)0.003 5/362011
cervix (1/7)0.002 1/28115
colon (10/853)1.000 27/165626
ear (1/2)0.007 3/12660
embryo (1/19)0.003 2/37976
eye (4/33)0.014 9/93836
foreskin (1/4)0.008 5/20040
germ cell (2/7)0.001 3/57383
head and neck (4/990)0.118 9/79796
heart (2/22)0.002 7/55494
kidney (3/86)0.004 6/132968
liver (1/38)0.041 1/46472
lung (11/312)0.005 17/245386
muscle (1/21)0.003 1/71297
oral cavity (2/18)0.020 28/44567
ovary (2/144)0.002 2/81880
pancreas (2/33)0.003 8/117255
parathyroid (1/4)0.005 3/19377
placenta (4/342)0.004 7/157762
prostate (6/291)0.004 7/109871
skin (2/31)0.001 2/100815
stomach (3/312)0.446 17/129930
testis (3/171)0.002 5/117531
umbilical cord (1/3)0.010 2/6185
uncharacterized tissue (22/1773)0.007 90/713325
uterus (3/212)0.001 3/155110
SAGE (9529577 tags, 178 libraries)
Tissue ? Frequency ? Count ?
blood (1/1)1.000 6/145569
brain (12/19)0.271 24/1335784
colon (7/8)0.285 13/672696
eye (4/6)0.522 17/1272091
heart (1/1)0.423 5/337428
kidney (1/2)0.356 2/64156
liver (1/1)0.256 2/66861
lung (1/1)0.464 5/356572
mammary gland (12/19)0.488 23/852304
muscle (1/2)0.159 1/53853
ovary (8/10)0.929 23/507730
pancreas (5/8)0.469 9/299895
prostate (10/13)0.399 24/1219476
skin (6/7)0.980 9/135531
stomach (2/3)0.511 7/404994
uncharacterized tissue (13/22)0.530 40/1407546
vascular (3/3)0.349 8/397091
SNPrs2859651 (G/T:locus-region);  rs2248293 (C/T:locus-region);  rs1234223 (G/A:locus-region);  rs1044322 (C/T:locus-region);  rs2616599 (T/C:locus-region);  rs1234213 (T/C:locus-region);  rs2447621 (G/A:locus-region);  rs2459116 (T/G:locus-region);  rs575687 (G/T:locus-region);  rs2471994 (A/G:locus-region);  rs2785074 (A/G:locus-region);  rs2673804 (C/T:locus-region);  rs2943772 (C/G:locus-region);  rs2516285 (A/C:locus-region);  rs1236816 (C/A:locus-region);  rs926091 (C/T:locus-region);  rs2736623 (A/C:locus-region);  rs2975557 (C/G:locus-region);  rs532678 (C/T:locus-region);  rs555895 (T/G:locus-region);  rs741804 (A/C:locus-region);  rs1903858 (A/T:locus-region);  rs2735358 (A/G:locus-region);  rs806677 (C/T:locus-region);  rs2673831 (G/A:locus-region);  rs1676759 (T/C:locus-region);  rs2673828 (C/T:locus-region);  rs2735343 (T/G:locus-region);  rs1044487 (C/G:locus-region);  rs2299939 (A/G:locus-region);  
EvidenceGross deletion in Prostate cancer Mutation in Prostate cancer Polymorphism in Benign prostate hyperplasia Polymorphism in Prostate cancer
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Department of Urology
Universityof California, San Francisco