| Name | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| Symbol | CDKN1B |
| Aliases | KIP1; CDKN4; P27KIP1 |
| Gene Product | - cyclin-dependent kinase inhibitor 1B
|
| Category | - Methylation in Prostate cancer
- Mutation in Prostate cancer
|
| UniGene | Hs.238990 |
| OMIM | 600778 |
| Locus | 1027 |
| Summary | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. |
| Gene Ontology | |
| Expression | | EST (191 ESTs, 110 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| adrenal gland (2/15) |  | 2/17521 |
| blood (1/27) | | 1/40686 |
| bone (1/13) | | 1/26211 |
| bone marrow (1/263) | | 1/38555 |
| brain (15/204) | | 24/362011 |
| cartilage (2/5) | | 4/11018 |
| cervix (2/7) | | 4/28115 |
| colon (7/853) | | 10/165626 |
| ear (1/2) | | 5/12660 |
| embryo (2/19) | | 6/37976 |
| esophagus (1/6) | | 2/3022 |
| eye (4/33) | | 5/93836 |
| foreskin (1/4) | | 2/20040 |
| germ cell (2/7) | | 3/57383 |
| head and neck (1/990) | | 1/79796 |
| kidney (5/86) | | 8/132968 |
| liver (3/38) | | 5/46472 |
| lung (6/312) | | 10/245386 |
| mammary gland (1/1) | | 2/2313 |
| muscle (2/21) | | 3/71297 |
| oral cavity (1/18) | | 4/44567 |
| ovary (4/144) | | 7/81880 |
| pancreas (2/33) | | 7/117255 |
| parathyroid (1/4) | | 1/19377 |
| placenta (5/342) | | 14/157762 |
| prostate (3/291) |  | 3/109871 |
| skin (1/31) | | 1/100815 |
| stomach (3/312) | | 3/129930 |
| testis (6/171) | | 9/117531 |
| thymus (1/17) | | 2/5021 |
| uncharacterized tissue (20/1773) | | 35/713325 |
| uterus (3/212) | | 6/155110 |
|
| SAGE (10282063 tags, 190 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/1) | | 3/145569 |
| brain (17/19) | | 76/1938809 |
| cerebellum (1/1) | | 6/205120 |
| colon (7/8) | | 16/743138 |
| eye (5/6) | | 38/1123583 |
| heart (1/1) | | 5/84357 |
| kidney (2/2) | | 8/179948 |
| liver (1/1) | | 5/200583 |
| lung (1/1) | | 14/534858 |
| mammary gland (15/19) | | 41/1301093 |
| muscle (2/2) | | 2/107728 |
| ovary (5/10) | | 9/269738 |
| pancreas (4/8) | | 9/267171 |
| prostate (12/13) | | 32/1054199 |
| skin (1/7) | | 1/8851 |
| stomach (2/3) | | 23/413796 |
| uncharacterized tissue (14/22) | | 66/1464192 |
| vascular (3/3) | | 14/239330 |
|
|
| SNP | rs3093728 (A/G:mrna-utr); rs2417224 (C/T:locus-region); rs34326 (T/C:mrna-utr); rs10237 (C/A:mrna-utr); rs2066827 (C/T:coding-nonsyn); rs248743 (C/T:locus-region); rs2277396 (T/C:mrna-utr); rs1042935 (C/T:mrna-utr); rs7330 (C/A:mrna-utr); rs2080747 (G/T:locus-region); |
| Evidence | Methylation in Prostate cancer
Mutation in Prostate cancer
|
