| Name | Fas (TNFRSF6) associated factor 1 |
| Symbol | FAF1 |
| Aliases | HFAF1; CGI-03; HFAF1s; TNFRSF6-associated factor 1 |
| Gene Product | - FAS-associated factor 1, isoform b
- FAS-associated factor 1, isoform a
|
| Category | - Methylation in Prostate cancer
|
| UniGene | Hs.25821 |
| OMIM | 604460 |
| Locus | 11124 |
| Summary | Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. Two transcript variants encoding different protein isoforms have been described for this gene. |
| Gene Ontology | |
| Expression | | EST (385 ESTs, 128 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| b cells (1/1) |  | 5/16734 |
| blood (2/27) | | 4/40686 |
| bone (2/13) | | 4/26211 |
| brain (10/204) | | 24/362011 |
| cervix (1/7) | | 1/28115 |
| colon (9/853) | | 14/165626 |
| embryo (1/19) | | 3/37976 |
| eye (3/33) | | 9/93836 |
| foreskin (1/4) | | 4/20040 |
| germ cell (1/7) | | 2/57383 |
| head and neck (6/990) | | 8/79796 |
| heart (2/22) | | 8/55494 |
| kidney (4/86) | | 13/132968 |
| liver (1/38) | | 2/46472 |
| lung (12/312) | | 22/245386 |
| muscle (3/21) | | 23/71297 |
| nervous (3/475) | | 3/43438 |
| oral cavity (1/18) | | 5/44567 |
| ovary (4/144) | | 13/81880 |
| pancreas (3/33) | | 8/117255 |
| placenta (3/342) | | 7/157762 |
| prostate (2/291) |  | 7/109871 |
| skin (4/31) | | 9/100815 |
| spleen (1/7) | | 1/9511 |
| stomach (7/312) | | 9/129930 |
| testis (5/171) | | 13/117531 |
| thymus (1/17) | | 1/5021 |
| uncharacterized tissue (26/1773) | | 145/713325 |
| uterus (9/212) | | 18/155110 |
|
| SAGE (10445435 tags, 193 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/1) | | 2/97046 |
| brain (16/19) | | 51/2265634 |
| cerebellum (1/1) | | 2/102560 |
| colon (7/8) | | 24/1013983 |
| eye (5/6) | | 21/1180540 |
| heart (1/1) | | 1/84357 |
| kidney (1/2) | | 2/64156 |
| liver (1/1) | | 1/66861 |
| mammary gland (9/19) | | 20/745427 |
| muscle (2/2) | | 5/161581 |
| ovary (9/10) | | 17/498819 |
| pancreas (5/8) | | 8/304205 |
| prostate (11/13) | | 25/1038218 |
| skin (2/7) | | 3/35943 |
| stomach (3/3) | | 14/459999 |
| uncharacterized tissue (17/22) | | 47/1760428 |
| vascular (3/3) | | 9/565678 |
|
|
| SNP | rs2644544 (A/G:intron); rs2095864 (C/T:intron); rs1149790 (A/G:intron); rs2102038 (G/A:intron); rs1573011 (C/T:intron); rs1972100 (A/G:intron); rs1513640 (C/T:intron); rs1278636 (T/G:intron); rs3033415 (-/TTTATTT:intron); rs1935301 (A/G:intron); rs1278748 (C/T:intron); rs2405004 (C/T:intron); rs946499 (A/G:intron); rs2207075 (G/A:intron); rs2789899 (A/G:intron); rs1278513 (G/T:mrna-utr); rs2153765 (T/G:intron); rs1474784 (C/G:intron); rs1846522 (A/G:intron); rs2105211 (G/C:intron); rs956084 (A/G:intron); rs1499441 (A/G:intron); rs1416685 (C/G:intron); rs1334414 (C/T:intron); rs967584 (T/G:intron); rs718257 (C/T:intron); rs2090013 (C/T:intron); rs2048636 (C/G:intron); rs3033489 (AT/-:intron); rs2221933 (C/A:intron); rs1464081 (C/T:intron); rs1015085 (G/T:intron); rs1849553 (C/T:intron); rs2896886 (C/T:intron); rs1398868 (A/G:intron); |
| Evidence | Methylation in Prostate cancer
|
