Human

Human Prostate Gene DataBase
Name v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Symbol ERBB2
Aliases NEU; NGL; HER2; HER-2; Avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
Gene Product
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Category
  • Amplification in Prostate cancer
UniGeneHs.323910
OMIM164870
Locus2064
SummaryTyrosine kinase receptor, a component of IL-6 signalling through the MAP kinase pathway; similar to the EGF receptor
Gene Ontology
Expression
EST (266 ESTs, 155 libraries)
Tissue ? Frequency ? Count ?
bone marrow (2/263)0.006 2/38555
brain (5/204)0.005 6/362011
colon (34/853)0.362 63/165626
embryo (1/19)0.007 4/37976
eye (4/33)0.214 10/93836
head and neck (8/990)1.000 12/79796
heart (1/22)0.002 2/55494
intestine (1/4)0.015 4/11528
kidney (3/86)0.955 3/132968
lung (5/312)0.010 9/245386
muscle (2/21)0.008 7/71297
nervous (1/475)0.048 1/43438
oral cavity (1/18)0.002 2/44567
ovary (4/144)0.110 7/81880
pancreas (4/33)0.002 7/117255
placenta (14/342)0.183 20/157762
prostate (5/291)0.012 7/109871
skin (1/31)0.005 1/100815
spleen (1/7)0.009 1/9511
stomach (9/312)0.058 13/129930
testis (1/171)0.006 3/117531
uncharacterized tissue (41/1773)0.009 73/713325
uterus (5/212)0.010 7/155110
SAGE (8882218 tags, 180 libraries)
Tissue ? Frequency ? Count ?
brain (13/19)0.112 27/1157884
cerebellum (1/1)0.137 2/102560
colon (8/8)0.175 24/837255
eye (5/6)0.088 7/489513
heart (1/1)0.078 3/253071
kidney (2/2)0.155 4/73935
liver (1/1)0.092 3/200583
lung (1/1)0.118 4/178286
mammary gland (12/19)0.606 108/1358570
muscle (2/2)1.000 38/269309
ovary (6/10)0.422 15/313345
pancreas (7/8)0.317 26/478962
prostate (11/13)0.253 47/958610
skin (4/7)0.231 6/62013
stomach (2/3)0.385 16/409395
uncharacterized tissue (17/22)0.670 118/1610180
vascular (2/3)0.038 2/128747
SNPrs272159 (G/A:exception);  rs1058808 (C/G:exception);  rs2952154 (G/A:exception);  rs2904764 (G/A:locus-region);  rs2313170 (A/G:exception);  rs1565923 (A/G:exception);  rs445358 (A/G:exception);  rs2643193 (A/G:locus-region);  rs2517951 (T/C:locus-region);  rs2088126 (A/G:exception);  rs1801200 (G/A:exception);  rs387082 (T/N:exception);  rs169244 (G/A:exception);  rs1810132 (C/T:exception);  rs2172826 (C/G:exception);  rs2230700 (G/T:mrna-utr);  rs2934967 (G/T:locus-region);  rs903506 (A/G:exception);  rs2517959 (C/A:locus-region);  
EvidenceAmplification in Prostate cancer
© 2002, PGDB, All Rights Reserved.
Department of Urology
Universityof California, San Francisco