HPC1 - hereditary prostate cancer 1

Human Prostate Gene DataBase

Name	hereditary prostate cancer 1
Symbol	HPC1
Aliases	PRCA1; prostate cancer 1
Category	Linkage in Prostate cancer
OMIM	601518
Locus	5513
Evidence	Linkage in Prostate cancer PCAP is the major known prostate cancer predisposing locus in familiesfrom south and west Europe. Eur J Hum Genet 2001 Feb;9(2):135-42. Germline mutations in the ribonuclease L gene in families showing linkagewith HPC1. Nat Genet 2002 Feb;30(2):181-4. Genetic alterations in untreated metastases and androgen-independentprostate cancer detected by comparative genomic hybridization andallelotyping. Cancer Res 1996 Jul 1;56(13):3091-102. Linkage analysis of chromosome 1q markers in 136 prostate cancer families.The Cancer Research Campaign/British Prostate Group U.K. Familial ProstateCancer Study Collaborators. Am J Hum Genet 1998 Mar;62(3):653-8. In Swedish families with hereditary prostate cancer, linkage to the HPC1locus on chromosome 1q24-25 is restricted to families with early-onsetprostate cancer. Am J Hum Genet 1999 Jul;65(1):134-40. Linkage analysis of 49 high-risk families does not support a commonfamilial prostate cancer-susceptibility gene at 1q24-25. Am J Hum Genet 1997 Aug;61(2):347-53. Prostate cancer susceptibility locus HPC1 in Utah high-risk pedigrees. Hum Mol Genet 1999 Dec;8(13):2437-42. Major susceptibility locus for prostate cancer on chromosome 1 suggestedby a genome-wide search. Science 1996 Nov 22;274(5291):1371-4. Combined analysis of hereditary prostate cancer linkage to 1q24-25:results from 772 hereditary prostate cancer families from theInternational Consortium for Prostate Cancer Genetics. Am J Hum Genet 2000 Mar;66(3):945-57.