Human

Human Prostate Gene DataBase
Name 8-oxoguanine DNA glycosylase
Symbol OGG1
Aliases HMMH; MUTM; OGH1; HOGG1; 8-hydroxyguanine DNA glycosylase
Gene Product
  • 8-oxoguanine DNA glycosylase, isoform 2d
  • 8-oxoguanine DNA glycosylase, isoform 1b
  • 8-oxoguanine DNA glycosylase, isoform 2c
  • 8-oxoguanine DNA glycosylase, isoform 2a
  • 8-oxoguanine DNA glycosylase, isoform 1a
  • 8-oxoguanine DNA glycosylase, isoform 2e
  • 8-oxoguanine DNA glycosylase, isoform 1c
  • 8-oxoguanine DNA glycosylase, isoform 2b
Category
  • Mutation in Prostate cancer
UniGeneHs.96398
OMIM601982
Locus4968
SummaryThis gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. The N-terminus of this gene contains a mitochondrial targetting signal, essential for mitochondrial localization.
Gene Ontology
Expression
EST (156 ESTs, 76 libraries)
Tissue ? Frequency ? Count ?
blood (1/27)0.008 2/40686
brain (16/204)0.005 34/362011
cervix (1/7)0.005 4/28115
colon (2/853)0.002 4/165626
embryo (1/19)0.001 1/37976
eye (4/33)0.003 9/93836
germ cell (1/7)0.001 2/57383
head and neck (1/990)0.080 1/79796
kidney (4/86)0.002 15/132968
lung (6/312)0.001 9/245386
oral cavity (2/18)0.004 8/44567
pancreas (1/33)0.003 1/117255
placenta (4/342)0.148 11/157762
prostate (7/291)1.000 11/109871
skin (1/31)0.001 1/100815
stomach (6/312)0.005 11/129930
testis (2/171)0.005 2/117531
thymus (1/17)0.008 1/5021
uncharacterized tissue (11/1773)0.209 24/713325
uterus (4/212)0.002 5/155110
SAGE (10433800 tags, 207 libraries)
Tissue ? Frequency ? Count ?
blood (1/1)0.095 1/48523
brain (17/19)0.541 61/1916381
cerebellum (1/1)0.120 1/51280
colon (7/8)0.711 28/1175992
eye (5/6)0.416 10/650511
heart (1/1)0.293 4/253071
kidney (2/2)0.207 2/73935
liver (1/1)0.139 1/66861
lung (1/1)0.243 3/178286
mammary gland (16/19)0.805 73/1166582
muscle (2/2)0.287 4/215456
ovary (9/10)0.795 22/552465
pancreas (5/8)0.573 12/393808
prostate (12/13)0.564 35/1327986
skin (4/7)1.000 6/88514
stomach (3/3)0.244 5/302633
uncharacterized tissue (15/22)0.671 54/1387674
vascular (3/3)0.480 13/583842
SNPrs2072668 (G/C:intron);  rs1052133 (C/G:coding-nonsyn);  rs812536 (C/T:intron);  rs159150 (C/T:intron);  rs809784 (A/T:intron);  rs1801126 (G/A:mrna-utr);  rs1182801 (C/G:intron);  rs1053072 (G/A:locus-region);  rs810862 (C/T:intron);  rs2069058 (T/A:locus-region);  rs2472031 (C/G:intron);  rs415153 (T/A:intron);  rs2619496 (T/A:intron);  rs786512 (T/G:intron);  rs1805373 (A/G:coding-nonsyn);  rs1052138 (C/T:coding-nonsyn);  rs293794 (T/C:locus-region);  rs809256 (T/C:intron);  rs2471894 (T/C:intron);  rs2075747 (G/A:intron);  rs125701 (A/G:locus-region);  rs615501 (G/A:locus-region);  rs2304276 (G/A:locus-region);  rs1164274 (A/T:locus-region);  
EvidenceMutation in Prostate cancer
© 2002, PGDB, All Rights Reserved.
Department of Urology
Universityof California, San Francisco