| Name | stathmin 1/oncoprotein 18 |
| Symbol | STMN1 |
| Aliases | SMN; OP18; PP17; PP19; PR22; LAP18; prosolin; stathmin; metablastin; oncoprotein 18; phosphoprotein 19; leukemia-associated phosphoprotein p18 |
| Gene Product | |
| Category | - Methylation in Prostate cancer
|
| UniGene | Hs.250811 |
| OMIM | 151442 |
| Locus | 3925 |
| Summary | This gene encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. A possible role for this gene in growth regulation, as well as its expression pattern and chromosomal location, suggests an involvement in the development of neuroblastomas and melanomas. |
| Gene Ontology | |
| Expression | | EST (1358 ESTs, 298 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| adrenal gland (4/15) |  | 13/17521 |
| b cells (1/1) | | 3/16734 |
| blood (7/27) | | 31/40686 |
| bone (4/13) | | 20/26211 |
| bone marrow (4/263) | | 25/38555 |
| brain (39/204) | | 216/362011 |
| cervix (2/7) | | 10/28115 |
| colon (16/853) | | 31/165626 |
| ear (1/2) | | 8/12660 |
| embryo (7/19) | | 12/37976 |
| esophagus (1/6) | | 2/3022 |
| eye (7/33) | | 86/93836 |
| foreskin (1/4) | | 10/20040 |
| germ cell (3/7) | | 10/57383 |
| head and neck (4/990) | | 5/79796 |
| heart (5/22) | | 38/55494 |
| intestine (1/4) | | 5/11528 |
| kidney (12/86) | | 23/132968 |
| liver (4/38) | | 10/46472 |
| lung (18/312) | | 101/245386 |
| muscle (4/21) | | 16/71297 |
| nervous (6/475) | | 7/43438 |
| oral cavity (2/18) | | 2/44567 |
| ovary (10/144) | | 19/81880 |
| pancreas (4/33) | | 11/117255 |
| parathyroid (1/4) | | 5/19377 |
| placenta (7/342) | | 37/157762 |
| prostate (12/291) |  | 27/109871 |
| skin (6/31) | | 41/100815 |
| spleen (1/7) | | 4/9511 |
| stomach (13/312) | | 31/129930 |
| t cells (1/2) | | 6/4729 |
| testis (9/171) | | 155/117531 |
| thymus (6/17) | | 10/5021 |
| umbilical cord (1/3) | | 7/6185 |
| uncharacterized tissue (60/1773) | | 185/713325 |
| uterus (12/212) | | 133/155110 |
|
| SAGE (30963175 tags, 583 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/1) | | 10/97046 |
| brain (19/19) | | 560/7834586 |
| cerebellum (1/1) | | 11/256400 |
| colon (8/8) | | 100/2271823 |
| eye (6/6) | | 74/3228299 |
| foreskin (2/2) | | 7/38250 |
| heart (1/1) | | 22/337428 |
| kidney (2/2) | | 20/295740 |
| liver (1/1) | | 10/200583 |
| lung (1/1) | | 25/534858 |
| mammary gland (18/19) | | 297/3133778 |
| muscle (2/2) | | 26/377037 |
| ovary (10/10) | | 102/1102083 |
| pancreas (8/8) | | 81/1107113 |
| prostate (12/13) | | 165/3947076 |
| skin (5/7) | | 37/156172 |
| stomach (3/3) | | 38/1052062 |
| uncharacterized tissue (20/22) | | 273/3678246 |
| vascular (3/3) | | 69/1314595 |
|
|
| SNP | rs213641 (G/T:mrna-utr); rs916142 (A/G:intron); rs809388 (G/A:locus-region); rs182455 (T/C:locus-region); rs2857303 (G/T:intron); rs1157182 (A/C:intron); rs159531 (T/C:intron); rs1063719 (T/A:mrna-utr); rs1804096 (A/G:mrna-utr); rs2565037 (A/T:locus-region); rs1051170 (G/T:coding-nonsyn); |
| Evidence | Methylation in Prostate cancer
|
