| Name | inhibin, alpha |
| Symbol | INHA |
| Aliases | A-inhibin subunit precursor |
| Gene Product | - inhibin alpha subunit precursor
|
| Category | - Gross deletion in Prostate cancer
- Methylation in Prostate cancer
|
| UniGene | Hs.1734 |
| OMIM | 147380 |
| Locus | 3623 |
| Summary | The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. |
| Gene Ontology | |
| Expression | | EST (49 ESTs, 21 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| brain (2/204) |  | 9/362011 |
| eye (1/33) | | 2/93836 |
| germ cell (3/7) | | 7/57383 |
| head and neck (1/990) | | 1/79796 |
| ovary (2/144) | | 6/81880 |
| placenta (4/342) | | 7/157762 |
| testis (1/171) | | 3/117531 |
| uncharacterized tissue (6/1773) | | 13/713325 |
| uterus (1/212) | | 1/155110 |
|
| SAGE (8997642 tags, 174 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/1) | | 5/97046 |
| brain (19/19) | | 80/2240179 |
| cerebellum (1/1) | | 3/153840 |
| colon (7/8) | | 18/682724 |
| eye (4/6) | | 13/434325 |
| heart (1/1) | | 9/253071 |
| kidney (2/2) | | 6/115792 |
| liver (1/1) | | 5/66861 |
| lung (1/1) | | 8/178286 |
| mammary gland (18/19) | | 59/1239085 |
| muscle (1/2) | | 1/53875 |
| ovary (7/10) | | 40/422460 |
| pancreas (8/8) | | 14/318496 |
| prostate (13/13) |  | 79/1052776 |
| skin (4/7) | | 11/57393 |
| stomach (2/3) | | 12/343363 |
| uncharacterized tissue (17/22) | | 67/1025151 |
| vascular (3/3) | | 15/262919 |
|
|
| SNP | rs1061399 (A/G:locus-region); rs186208 (T/C:intron); rs2229913 (G/T:mrna-utr); |
| Evidence | Gross deletion in Prostate cancer
Methylation in Prostate cancer
|
