| Name | bone morphogenetic protein 6 |
| Symbol | BMP6 |
| Aliases | VGR1; Vg-related sequence; transforming growth factor-beta |
| Gene Product | - bone morphogenetic protein 6 precursor
|
| Category | - Methylation in Prostate cancer
|
| UniGene | Hs.285671 |
| OMIM | 112266 |
| Locus | 654 |
| Summary | Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Through molecular cloning, 7 BMP cDNAs, designated BMP1 through BMP7, have been recovered. BMP2 through BMP7, are members of the transforming growth factor-beta superfamily of regulatory molecules. From a high degree of amino acid sequence homology, BMP5, BMP6, and BMP7 are recognized as a subfamily of the BMPs. |
| Gene Ontology | |
| Expression | | EST (28 ESTs, 18 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/27) |  | 1/40686 |
| brain (1/204) | | 1/362011 |
| cervix (1/7) | | 1/28115 |
| eye (1/33) | | 2/93836 |
| kidney (1/86) | | 1/132968 |
| lung (1/312) | | 1/245386 |
| ovary (2/144) | | 8/81880 |
| placenta (1/342) | | 3/157762 |
| prostate (2/291) |  | 2/109871 |
| uncharacterized tissue (7/1773) | | 8/713325 |
|
| SAGE (1996935 tags, 34 libraries) |
| Tissue ? |
Frequency ? |
Count ? |
| blood (1/1) | | 1/48523 |
| brain (3/19) | | 4/144030 |
| colon (3/8) | | 4/226026 |
| eye (2/6) | | 3/264379 |
| heart (1/1) | | 1/84357 |
| kidney (1/2) | | 1/41857 |
| liver (1/1) | | 1/66861 |
| lung (1/1) | | 1/89143 |
| ovary (4/10) | | 4/151012 |
| pancreas (1/8) | | 1/37962 |
| prostate (5/13) | | 18/393059 |
| uncharacterized tissue (4/22) | | 5/262975 |
| vascular (3/3) | | 13/186751 |
|
|
| SNP | rs1225986 (A/C:intron); rs911747 (C/T:locus-region); rs2038585 (A/G:intron); rs1150890 (T/A:intron); rs1160859 (-/AG:intron); rs881891 (C/G:intron); rs140750 (-/TAACT:intron); rs1358893 (A/G:intron); rs765944 (A/G:intron); rs1535429 (C/T:intron); rs189727 (G/A:intron); rs1322177 (C/T:intron); rs2327008 (A/G:intron); rs747418 (C/T:intron); rs2013263 (A/G:intron); rs911749 (A/C:intron); rs1407361 (C/T:intron); rs956702 (A/G:intron); rs199205 (C/G:intron); rs2208674 (A/C:intron); rs932659 (A/G:intron); rs927400 (A/G:intron); rs2224563 (G/C:intron); rs1923409 (C/T:intron); rs2068361 (A/G:intron); rs2876113 (G/T:intron); rs98899 (A/G:intron); rs752479 (A/C:intron); rs927416 (C/T:intron); rs270373 (C/T:intron); rs1226099 (A/G:intron); rs3031753 (-/AAT:intron); rs1107495 (C/T:locus-region); rs2876117 (A/C:intron); rs2757130 (G/A:intron); rs2146015 (A/T:intron); rs2326994 (C/T:intron); rs1322241 (A/G:intron); rs2007473 (G/T:intron); rs1885448 (C/G:intron); rs733954 (C/G:intron); rs735666 (A/T:intron); rs1001566 (C/T:intron); rs2057372 (A/C:intron); rs3031043 (-/GAAT:intron); rs736681 (C/T:intron); |
| Evidence | Methylation in Prostate cancer
|
