Human

Human Kidney Gene DataBase
Name apolipoprotein E
Symbol APOE
Aliases
Gene Product
  • apolipoprotein E
Category
UniGene Hs.110675 
Reference Sequence
mRNA: NM_000041 Protein: NP_000032
OMIM and SNP
OMIM: 107741 SNP: NCBI SNP
Locus
LocusLink: 348Chromosome: 19Cytoband: 19q13.2 UCSC Genome Map Eesembl Genome Map
SummaryChylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Gene Ontology
Expression
EST (1350 ESTs, 164 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 32 libraries express this gene (3.12%)Average CPM:0.06
boneBreadth of expression: 6 out of 24 libraries express this gene (25.00%)Average CPM:0.28
brainBreadth of expression: 26 out of 759 libraries express this gene (3.43%)Average CPM:2.99
cartilageBreadth of expression: 3 out of 16 libraries express this gene (18.75%)Average CPM:1.13
cervixBreadth of expression: 2 out of 11 libraries express this gene (18.18%)Average CPM:1.80
colonBreadth of expression: 9 out of 930 libraries express this gene (0.97%)Average CPM:6.47
esophagusBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:0.27
eyeBreadth of expression: 5 out of 24 libraries express this gene (20.83%)Average CPM:0.14
germ cellBreadth of expression: 4 out of 6 libraries express this gene (66.67%)Average CPM:1.24
head and neckBreadth of expression: 5 out of 680 libraries express this gene (0.74%)Average CPM:8.82
heartBreadth of expression: 1 out of 26 libraries express this gene (3.85%)Average CPM:0.16
kidneyBreadth of expression: 6 out of 145 libraries express this gene (4.14%)Average CPM:1.52
liverBreadth of expression: 8 out of 65 libraries express this gene (12.31%)Average CPM:2.67
lungBreadth of expression: 10 out of 334 libraries express this gene (2.99%)Average CPM:0.21
lymph nodeBreadth of expression: 2 out of 22 libraries express this gene (9.09%)Average CPM:3.55
mammary glandBreadth of expression: 4 out of 1038 libraries express this gene (0.39%)Average CPM:6.25
muscleBreadth of expression: 1 out of 83 libraries express this gene (1.20%)Average CPM:0.05
nervousBreadth of expression: 4 out of 21 libraries express this gene (19.05%)Average CPM:0.23
ovaryBreadth of expression: 7 out of 170 libraries express this gene (4.12%)Average CPM:10.74
pancreasBreadth of expression: 2 out of 20 libraries express this gene (10.00%)Average CPM:0.13
parathyroidBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.04
placentaBreadth of expression: 3 out of 358 libraries express this gene (0.84%)Average CPM:0.89
prostateBreadth of expression: 4 out of 309 libraries express this gene (1.29%)Average CPM:0.14
skinBreadth of expression: 4 out of 38 libraries express this gene (10.53%)Average CPM:6.74
spleenBreadth of expression: 1 out of 15 libraries express this gene (6.67%)Average CPM:1.58
stomachBreadth of expression: 3 out of 310 libraries express this gene (0.97%)Average CPM:0.04
testisBreadth of expression: 4 out of 180 libraries express this gene (2.22%)Average CPM:0.05
thymusBreadth of expression: 1 out of 23 libraries express this gene (4.35%)Average CPM:0.23
uncharacterized tissueBreadth of expression: 27 out of 1739 libraries express this gene (1.55%)Average CPM:0.33
uterusBreadth of expression: 6 out of 236 libraries express this gene (2.54%)Average CPM:0.19
vascularBreadth of expression: 1 out of 18 libraries express this gene (5.56%)Average CPM:0.65
whole bodyBreadth of expression: 1 out of 12 libraries express this gene (8.33%)Average CPM:0.06
SAGE (225593 tags, 4 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 1 out of 30 libraries express this gene (3.33%)Average CPM:28.95
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:74.78
uncharacterized tissueBreadth of expression: 2 out of 20 libraries express this gene (10.00%)Average CPM:16.38
EvidencePolymorphism in End-Stage Renal Disease Polymorphism in Nephrotic Syndrome

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco