Human

Human Kidney Gene DataBase
Name interleukin 1 receptor antagonist
Symbol IL1RN
Aliases IRAP; IL1F3; IL1RA; ICIL-1RA; MGC10430; intracellular IL-1 receptor antagonist type II
Gene Product
  • interleukin 1 receptor antagonist isoform 3
  • interleukin 1 receptor antagonist isoform 2
  • interleukin 1 receptor antagonist isoform 4
  • interleukin 1 receptor antagonist isoform 1 precursor
Category
UniGene Hs.81134 
Reference Sequence
mRNA: NM_173843 Protein: NP_776215
OMIM and SNP
OMIM: 147679 SNP: NCBI SNP
Locus
LocusLink: 3557Chromosome: 2Cytoband: 2q14.2 UCSC Genome Map Eesembl Genome Map
SummaryThe protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene Ontology
Expression
EST (183 ESTs, 96 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 3 out of 32 libraries express this gene (9.38%)Average CPM:13.98
brainBreadth of expression: 5 out of 759 libraries express this gene (0.66%)Average CPM:0.42
colonBreadth of expression: 9 out of 930 libraries express this gene (0.97%)Average CPM:1.50
earBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.44
esophagusBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:1.97
eyeBreadth of expression: 1 out of 24 libraries express this gene (4.17%)Average CPM:0.54
germ cellBreadth of expression: 1 out of 6 libraries express this gene (16.67%)Average CPM:1.81
head and neckBreadth of expression: 19 out of 680 libraries express this gene (2.79%)Average CPM:390.32
heartBreadth of expression: 1 out of 26 libraries express this gene (3.85%)Average CPM:0.44
liverBreadth of expression: 5 out of 65 libraries express this gene (7.69%)Average CPM:4.17
lungBreadth of expression: 7 out of 334 libraries express this gene (2.10%)Average CPM:1.50
lymph nodeBreadth of expression: 1 out of 22 libraries express this gene (4.55%)Average CPM:0.13
mammary glandBreadth of expression: 2 out of 1038 libraries express this gene (0.19%)Average CPM:2.98
pancreasBreadth of expression: 2 out of 20 libraries express this gene (10.00%)Average CPM:2.57
placentaBreadth of expression: 2 out of 358 libraries express this gene (0.56%)Average CPM:1.29
skinBreadth of expression: 2 out of 38 libraries express this gene (5.26%)Average CPM:0.67
spleenBreadth of expression: 1 out of 15 libraries express this gene (6.67%)Average CPM:4.33
stomachBreadth of expression: 3 out of 310 libraries express this gene (0.97%)Average CPM:0.31
testisBreadth of expression: 2 out of 180 libraries express this gene (1.11%)Average CPM:0.86
uncharacterized tissueBreadth of expression: 21 out of 1739 libraries express this gene (1.21%)Average CPM:2.80
uterusBreadth of expression: 4 out of 236 libraries express this gene (1.69%)Average CPM:0.35
SAGE (6763583 tags, 126 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:103.04
brainBreadth of expression: 14 out of 30 libraries express this gene (46.67%)Average CPM:39.82
cervixBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:9205.08
colonBreadth of expression: 6 out of 8 libraries express this gene (75.00%)Average CPM:36.63
eyeBreadth of expression: 5 out of 6 libraries express this gene (83.33%)Average CPM:79.06
heartBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:11.85
kidneyBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:55.69
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:104.69
lungBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:11.22
mammary glandBreadth of expression: 7 out of 20 libraries express this gene (35.00%)Average CPM:148.37
muscleBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:18.56
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:54.13
ovaryBreadth of expression: 4 out of 10 libraries express this gene (40.00%)Average CPM:41.52
pancreasBreadth of expression: 3 out of 8 libraries express this gene (37.50%)Average CPM:74.44
prostateBreadth of expression: 5 out of 14 libraries express this gene (35.71%)Average CPM:33.85
skinBreadth of expression: 3 out of 7 libraries express this gene (42.86%)Average CPM:126.46
stomachBreadth of expression: 3 out of 4 libraries express this gene (75.00%)Average CPM:1587.11
uncharacterized tissueBreadth of expression: 10 out of 20 libraries express this gene (50.00%)Average CPM:54.76
vascularBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:32.15
EvidencePolymorphism in Nephrotic Syndrome

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco