Human

Human Kidney Gene DataBase

Name chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease)
Symbol CLCN5
Aliases XRN; CLC5; XLRH; CLCK2; DENTS; NPHL2; hCIC-K2; hClC-K2
Gene Product
  • chloride channel 5
Category
UniGene Hs.166486 
Reference Sequence
mRNA: NM_000084 Protein: NP_000075
OMIM and SNP
OMIM: 300008 SNP: NCBI SNP
Locus
LocusLink: 1184Chromosome: XCytoband: Xp11.23-p11.22 UCSC Genome Map Eesembl Genome Map
SummaryCLCN5 is a voltage-gated chloride channel. Mutation of this gene results in Dent disease and renal tubular disorders complicated by nephrolithiasis.
Gene Ontology
Expression
EST (176 ESTs, 78 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of  32 libraries express this gene (3.12%)Average CPM:0.90
boneBreadth of expression: 3 out of  24 libraries express this gene (12.50%)Average CPM:1.26
brainBreadth of expression: 5 out of  759 libraries express this gene (0.66%)Average CPM:0.29
cartilageBreadth of expression: 1 out of  16 libraries express this gene (6.25%)Average CPM:1.31
colonBreadth of expression: 1 out of  930 libraries express this gene (0.11%)Average CPM:24.92
earBreadth of expression: 1 out of  2 libraries express this gene (50.00%)Average CPM:1.36
embryoBreadth of expression: 1 out of  4 libraries express this gene (25.00%)Average CPM:2.09
eyeBreadth of expression: 3 out of  24 libraries express this gene (12.50%)Average CPM:1.10
germ cellBreadth of expression: 1 out of  6 libraries express this gene (16.67%)Average CPM:0.16
heartBreadth of expression: 1 out of  26 libraries express this gene (3.85%)Average CPM:0.31
kidneyBreadth of expression: 6 out of  145 libraries express this gene (4.14%)Average CPM:3.70
liverBreadth of expression: 1 out of  65 libraries express this gene (1.54%)Average CPM:3.27
lungBreadth of expression: 4 out of  334 libraries express this gene (1.20%)Average CPM:38.39
lymph nodeBreadth of expression: 1 out of  22 libraries express this gene (4.55%)Average CPM:0.26
mammary glandBreadth of expression: 1 out of  1038 libraries express this gene (0.10%)Average CPM:0.63
muscleBreadth of expression: 3 out of  83 libraries express this gene (3.61%)Average CPM:0.39
nervousBreadth of expression: 3 out of  21 libraries express this gene (14.29%)Average CPM:1.14
pancreasBreadth of expression: 1 out of  20 libraries express this gene (5.00%)Average CPM:0.38
placentaBreadth of expression: 3 out of  358 libraries express this gene (0.84%)Average CPM:1.87
prostateBreadth of expression: 1 out of  309 libraries express this gene (0.32%)Average CPM:1.47
skinBreadth of expression: 4 out of  38 libraries express this gene (10.53%)Average CPM:2.09
spleenBreadth of expression: 1 out of  15 libraries express this gene (6.67%)Average CPM:10.61
stomachBreadth of expression: 3 out of  310 libraries express this gene (0.97%)Average CPM:0.53
testisBreadth of expression: 2 out of  180 libraries express this gene (1.11%)Average CPM:0.13
uncharacterized tissueBreadth of expression: 19 out of  1739 libraries express this gene (1.09%)Average CPM:0.88
uterusBreadth of expression: 2 out of  236 libraries express this gene (0.85%)Average CPM:0.27
whole bodyBreadth of expression: 3 out of  12 libraries express this gene (25.00%)Average CPM:2.94
SAGE (1551116 tags, 26 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 5 out of  30 libraries express this gene (16.67%)Average CPM:14.20
cerebellumBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:19.50
colonBreadth of expression: 4 out of  8 libraries express this gene (50.00%)Average CPM:23.60
eyeBreadth of expression: 3 out of  6 libraries express this gene (50.00%)Average CPM:26.88
kidneyBreadth of expression: 1 out of  3 libraries express this gene (33.33%)Average CPM:23.89
mammary glandBreadth of expression: 2 out of  20 libraries express this gene (10.00%)Average CPM:16.50
mesothelial tissueBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:28.42
ovaryBreadth of expression: 1 out of  10 libraries express this gene (10.00%)Average CPM:23.56
prostateBreadth of expression: 1 out of  14 libraries express this gene (7.14%)Average CPM:14.57
stomachBreadth of expression: 1 out of  4 libraries express this gene (25.00%)Average CPM:14.20
uncharacterized tissueBreadth of expression: 1 out of  20 libraries express this gene (5.00%)Average CPM:17.52
vascularBreadth of expression: 1 out of  3 libraries express this gene (33.33%)Average CPM:57.06
EvidenceDeletion in Kidney Neoplasms Deletion in System Syndrom with Kidney Involvment Mutation in End-Stage Renal Disease Mutation in Nephrolithiasis Mutation in System Syndrom with Kidney Involvment

Other key publications related to this gene


© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco