Human

Human Kidney Gene DataBase
Name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Symbol ABCC1
Aliases MRP; ABCC; GS-X; MRP1; ABC29; multidrug resistance protein; multiple drug resistance protein 1; multiple drug resistance-associated protein
Gene Product
  • ATP-binding cassette, sub-family C, member 1 isoform 5
  • ATP-binding cassette, sub-family C, member 1 isoform 1
  • ATP-binding cassette, sub-family C, member 1 isoform 3
  • ATP-binding cassette, sub-family C, member 1 isoform 7
  • ATP-binding cassette, sub-family C, member 1 isoform 6
  • ATP-binding cassette, sub-family C, member 1 isoform 4
  • ATP-binding cassette, sub-family C, member 1 isoform 2
Category
UniGene Hs.391464 
Reference Sequence
mRNA: NM_019902 Protein: NP_063957
OMIM and SNP
OMIM: 158343 SNP: NCBI SNP
Locus
LocusLink: 4363Chromosome: 16Cytoband: 16p13.1 UCSC Genome Map Eesembl Genome Map
SummaryThe protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
Gene Ontology
Expression
EST (241 ESTs, 131 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 32 libraries express this gene (3.12%)Average CPM:0.36
boneBreadth of expression: 2 out of 24 libraries express this gene (8.33%)Average CPM:1.05
bone marrowBreadth of expression: 2 out of 22 libraries express this gene (9.09%)Average CPM:7.35
brainBreadth of expression: 11 out of 759 libraries express this gene (1.45%)Average CPM:2.31
cartilageBreadth of expression: 6 out of 16 libraries express this gene (37.50%)Average CPM:1.58
cervixBreadth of expression: 2 out of 11 libraries express this gene (18.18%)Average CPM:1.73
colonBreadth of expression: 14 out of 930 libraries express this gene (1.51%)Average CPM:21.39
eyeBreadth of expression: 5 out of 24 libraries express this gene (20.83%)Average CPM:2.25
germ cellBreadth of expression: 1 out of 6 libraries express this gene (16.67%)Average CPM:0.34
head and neckBreadth of expression: 8 out of 680 libraries express this gene (1.18%)Average CPM:10.48
kidneyBreadth of expression: 3 out of 145 libraries express this gene (2.07%)Average CPM:27.30
liverBreadth of expression: 1 out of 65 libraries express this gene (1.54%)Average CPM:0.28
lungBreadth of expression: 9 out of 334 libraries express this gene (2.69%)Average CPM:21.84
lymph nodeBreadth of expression: 6 out of 22 libraries express this gene (27.27%)Average CPM:1.05
mammary glandBreadth of expression: 4 out of 1038 libraries express this gene (0.39%)Average CPM:52.52
muscleBreadth of expression: 2 out of 83 libraries express this gene (2.41%)Average CPM:0.17
nervousBreadth of expression: 3 out of 21 libraries express this gene (14.29%)Average CPM:1.43
ovaryBreadth of expression: 3 out of 170 libraries express this gene (1.76%)Average CPM:0.41
pancreasBreadth of expression: 2 out of 20 libraries express this gene (10.00%)Average CPM:1.67
parathyroidBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.60
placentaBreadth of expression: 1 out of 358 libraries express this gene (0.28%)Average CPM:0.40
prostateBreadth of expression: 4 out of 309 libraries express this gene (1.29%)Average CPM:34.87
skinBreadth of expression: 2 out of 38 libraries express this gene (5.26%)Average CPM:0.51
stomachBreadth of expression: 5 out of 310 libraries express this gene (1.61%)Average CPM:0.23
testisBreadth of expression: 3 out of 180 libraries express this gene (1.67%)Average CPM:1.29
uncharacterized tissueBreadth of expression: 19 out of 1739 libraries express this gene (1.09%)Average CPM:2.09
uterusBreadth of expression: 5 out of 236 libraries express this gene (2.12%)Average CPM:0.40
whole bodyBreadth of expression: 1 out of 12 libraries express this gene (8.33%)Average CPM:3.03
EvidenceAmplification in Kidney Neoplasms

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco