Human

Human Kidney Gene DataBase
Name adenomatosis polyposis coli
Symbol APC
Aliases GS; DP2; DP3; FAP; FPC; DP2.5
Gene Product
  • adenomatosis polyposis coli
Category
UniGene Hs.75081 
Reference Sequence
mRNA: NM_000038 Protein: NP_000029
OMIM and SNP
OMIM: 175100 SNP: NCBI SNP
Locus
LocusLink: 324Chromosome: 5Cytoband: 5q21-q22 UCSC Genome Map Eesembl Genome Map
SummaryThe metabolic function of the APC gene is not known. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Gene Ontology
Expression
EST (250 ESTs, 104 libraries)
Tissue Breadth ? CPM ?
adiposeBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:0.49
bloodBreadth of expression: 4 out of 32 libraries express this gene (12.50%)Average CPM:2.05
boneBreadth of expression: 2 out of 24 libraries express this gene (8.33%)Average CPM:0.94
brainBreadth of expression: 18 out of 759 libraries express this gene (2.37%)Average CPM:25.00
cartilageBreadth of expression: 2 out of 16 libraries express this gene (12.50%)Average CPM:1.31
cervixBreadth of expression: 1 out of 11 libraries express this gene (9.09%)Average CPM:0.20
colonBreadth of expression: 4 out of 930 libraries express this gene (0.43%)Average CPM:47.06
earBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.64
eyeBreadth of expression: 3 out of 24 libraries express this gene (12.50%)Average CPM:1.14
germ cellBreadth of expression: 1 out of 6 libraries express this gene (16.67%)Average CPM:0.11
head and neckBreadth of expression: 2 out of 680 libraries express this gene (0.29%)Average CPM:55.94
heartBreadth of expression: 2 out of 26 libraries express this gene (7.69%)Average CPM:0.67
kidneyBreadth of expression: 2 out of 145 libraries express this gene (1.38%)Average CPM:0.21
liverBreadth of expression: 1 out of 65 libraries express this gene (1.54%)Average CPM:5.62
lungBreadth of expression: 5 out of 334 libraries express this gene (1.50%)Average CPM:0.55
lymph nodeBreadth of expression: 4 out of 22 libraries express this gene (18.18%)Average CPM:0.59
mammary glandBreadth of expression: 4 out of 1038 libraries express this gene (0.39%)Average CPM:11.08
muscleBreadth of expression: 3 out of 83 libraries express this gene (3.61%)Average CPM:1.87
nervousBreadth of expression: 2 out of 21 libraries express this gene (9.52%)Average CPM:0.49
ovaryBreadth of expression: 2 out of 170 libraries express this gene (1.18%)Average CPM:6.97
pineal glandBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.91
placentaBreadth of expression: 2 out of 358 libraries express this gene (0.56%)Average CPM:0.49
prostateBreadth of expression: 1 out of 309 libraries express this gene (0.32%)Average CPM:5.63
skinBreadth of expression: 2 out of 38 libraries express this gene (5.26%)Average CPM:0.94
testisBreadth of expression: 4 out of 180 libraries express this gene (2.22%)Average CPM:0.21
uncharacterized tissueBreadth of expression: 18 out of 1739 libraries express this gene (1.04%)Average CPM:67.80
uterusBreadth of expression: 4 out of 236 libraries express this gene (1.69%)Average CPM:0.48
vascularBreadth of expression: 1 out of 18 libraries express this gene (5.56%)Average CPM:0.79
whole bodyBreadth of expression: 1 out of 12 libraries express this gene (8.33%)Average CPM:1.30
SAGE (9070056 tags, 157 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 23 out of 30 libraries express this gene (76.67%)Average CPM:71.77
cerebellumBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:39.00
cervixBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:98.63
colonBreadth of expression: 6 out of 8 libraries express this gene (75.00%)Average CPM:31.51
eyeBreadth of expression: 4 out of 6 libraries express this gene (66.67%)Average CPM:68.86
foreskinBreadth of expression: 2 out of 2 libraries express this gene (100.00%)Average CPM:103.88
heartBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:59.27
kidneyBreadth of expression: 3 out of 3 libraries express this gene (100.00%)Average CPM:33.88
lungBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:33.65
mammary glandBreadth of expression: 7 out of 20 libraries express this gene (35.00%)Average CPM:37.73
muscleBreadth of expression: 2 out of 2 libraries express this gene (100.00%)Average CPM:27.85
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:36.09
ovaryBreadth of expression: 6 out of 10 libraries express this gene (60.00%)Average CPM:56.41
pancreasBreadth of expression: 3 out of 8 libraries express this gene (37.50%)Average CPM:29.92
prostateBreadth of expression: 6 out of 14 libraries express this gene (42.86%)Average CPM:22.05
skinBreadth of expression: 2 out of 7 libraries express this gene (28.57%)Average CPM:80.95
stomachBreadth of expression: 2 out of 4 libraries express this gene (50.00%)Average CPM:22.24
uncharacterized tissueBreadth of expression: 12 out of 20 libraries express this gene (60.00%)Average CPM:52.69
vascularBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:23.80
EvidenceLOH in Kidney Neoplasms

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco