Human

Human Kidney Gene DataBase
Name apolipoprotein A-II
Symbol APOA2
Aliases
Gene Product
  • apolipoprotein A-II precursor
Category
UniGene Hs.237658 
Reference Sequence
mRNA: NM_001643 Protein: NP_001634
OMIM and SNP
OMIM: 107670 SNP: NCBI SNP
Locus
LocusLink: 336Chromosome: 1Cytoband: 1q21-q23 UCSC Genome Map Eesembl Genome Map
SummaryApolipoprotein (Apo-) A-II is the second most abundant protein of the high density lipoprotein particles. The apo-A-II gene consists of 4 exons and 3 introns. The four exons encode the 5' untranslated region, pre-peptide, a short N-terminal domain and a C-terminal domain composed of a variable number of lipid-binding amphipathic helices. Familial apo-A-II deficiency may result from a splice-junction alteration which blocks splicing of intron 3 from the primary transcript and result the formation of a non-functional mRNA.
Gene Ontology
Expression
EST (658 ESTs, 49 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 1 out of 759 libraries express this gene (0.13%)Average CPM:0.36
colonBreadth of expression: 1 out of 930 libraries express this gene (0.11%)Average CPM:0.13
germ cellBreadth of expression: 2 out of 6 libraries express this gene (33.33%)Average CPM:0.18
heartBreadth of expression: 1 out of 26 libraries express this gene (3.85%)Average CPM:0.78
kidneyBreadth of expression: 1 out of 145 libraries express this gene (0.69%)Average CPM:0.34
liverBreadth of expression: 19 out of 65 libraries express this gene (29.23%)Average CPM:24.32
lungBreadth of expression: 1 out of 334 libraries express this gene (0.30%)Average CPM:0.79
mammary glandBreadth of expression: 1 out of 1038 libraries express this gene (0.10%)Average CPM:0.24
muscleBreadth of expression: 1 out of 83 libraries express this gene (1.20%)Average CPM:0.28
placentaBreadth of expression: 1 out of 358 libraries express this gene (0.28%)Average CPM:0.50
spleenBreadth of expression: 2 out of 15 libraries express this gene (13.33%)Average CPM:14.76
testisBreadth of expression: 1 out of 180 libraries express this gene (0.56%)Average CPM:4.28
uncharacterized tissueBreadth of expression: 14 out of 1739 libraries express this gene (0.81%)Average CPM:5.58
whole bodyBreadth of expression: 1 out of 12 libraries express this gene (8.33%)Average CPM:0.25
SAGE (3728446 tags, 69 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 15 out of 30 libraries express this gene (50.00%)Average CPM:28.09
colonBreadth of expression: 4 out of 8 libraries express this gene (50.00%)Average CPM:95.83
eyeBreadth of expression: 3 out of 6 libraries express this gene (50.00%)Average CPM:14.96
heartBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:11.85
kidneyBreadth of expression: 1 out of 3 libraries express this gene (33.33%)Average CPM:22.97
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:1824.68
lungBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:22.44
mammary glandBreadth of expression: 2 out of 20 libraries express this gene (10.00%)Average CPM:28.06
mesothelial tissueBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:28.42
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:54.13
ovaryBreadth of expression: 4 out of 10 libraries express this gene (40.00%)Average CPM:44.24
pancreasBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:27.97
prostateBreadth of expression: 6 out of 14 libraries express this gene (42.86%)Average CPM:23.58
skinBreadth of expression: 2 out of 7 libraries express this gene (28.57%)Average CPM:76.21
uncharacterized tissueBreadth of expression: 9 out of 20 libraries express this gene (45.00%)Average CPM:64.13
EvidenceMutation in Renal Amyloidosis

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco