Human

Human Kidney Gene DataBase

Name bradykinin receptor B1
Symbol BDKRB1
Aliases B1R; BKR1; B1BKR; BRADYB1; BK-1 receptor; bradykinin receptor 1
Gene Product
  • bradykinin receptor B1
Category
UniGene Hs.46348 
Reference Sequence
mRNA: NM_000710 Protein: NP_000701
OMIM and SNP
OMIM: 600337 SNP: NCBI SNP
Locus
LocusLink: 623Chromosome: 14Cytoband: 14q32.1-q32.2 UCSC Genome Map Eesembl Genome Map
SummaryBradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.
Gene Ontology
Expression
EST (17 ESTs, 9 libraries)
Tissue Breadth ? CPM ?
boneBreadth of expression: 1 out of  24 libraries express this gene (4.17%)Average CPM:11.65
cartilageBreadth of expression: 3 out of  16 libraries express this gene (18.75%)Average CPM:18.38
cervixBreadth of expression: 1 out of  11 libraries express this gene (9.09%)Average CPM:66.92
kidneyBreadth of expression: 1 out of  145 libraries express this gene (0.69%)Average CPM:9.37
skinBreadth of expression: 2 out of  38 libraries express this gene (5.26%)Average CPM:14.11
SAGE (805888 tags, 15 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 3 out of  30 libraries express this gene (10.00%)Average CPM:23.20
colonBreadth of expression: 3 out of  8 libraries express this gene (37.50%)Average CPM:30.10
eyeBreadth of expression: 1 out of  6 libraries express this gene (16.67%)Average CPM:9.50
kidneyBreadth of expression: 1 out of  3 libraries express this gene (33.33%)Average CPM:23.89
mammary glandBreadth of expression: 1 out of  20 libraries express this gene (5.00%)Average CPM:82.36
prostateBreadth of expression: 2 out of  14 libraries express this gene (14.29%)Average CPM:30.00
uncharacterized tissueBreadth of expression: 2 out of  20 libraries express this gene (10.00%)Average CPM:28.00
EvidencePolymorphism in End-Stage Renal Disease

Other key publications related to this gene


© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco