| Name | carbonic anhydrase IX |
| Symbol | CA9 |
| Aliases | MN; carbonic dehydratase; RCC-associated protein G250 |
| Gene Product | - carbonic anhydrase IX precursor
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| Category | |
| UniGene |
Hs.63287
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| Reference Sequence |
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| OMIM and SNP |
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| Locus |
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| Summary | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. |
| Gene Ontology | |
| Expression | | EST (77 ESTs, 44 libraries) |
| Tissue | Breadth ? |
CPM ? |
| adipose |  | | | bone | | | | brain | | | | cartilage | | | | cervix | | | | colon | | | | kidney |  | | | lung | | | | nervous | | | | ovary | | | | pancreas | | | | placenta | | | | stomach | | | | testis | | | | thyroid | | | | uncharacterized tissue | | | | uterus | | |
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| SAGE (748731 tags, 14 libraries) |
| Tissue | Breadth ? |
CPM ? |
| brain | | | | colon | | | | eye | | | | mammary gland | | | | ovary | | | | pancreas | | | | prostate | | | | skin | | | | stomach | | | | uncharacterized tissue | | |
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| Evidence | Amplification in Kidney Neoplasms
Hypomethylation in Kidney Neoplasms
- Grabmaier K, de Weijert M, Uemura H, Schalken J, Oosterwijk E, Grabmaier K, de Weijert M, Uemura H, Schalken J, Oosterwijk E Renal cell carcinoma-associated G250 methylation and expression: in vivoand in vitro studies. Urology 2002 Aug;60(2):357-62.
- Cho M, Uemura H, Kim SC, Kawada Y, Yoshida K, Hirao Y, Konishi N, Saga S, Yoshikawa K, Cho M, Uemura H, Kim SC, Kawada Y, Yoshida K, Hirao Y, Konishi N, Saga S, Yoshikawa K Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expressionin human renal cell carcinoma. Br J Cancer 2001 Aug 17;85(4):563-7.
- Cho M, Grabmaier K, Kitahori Y, Hiasa Y, Nakagawa Y, Uemura H, Hirao Y, Ohnishi T, Yoshikawa K, Ooesterwijk E, Cho M, Grabmaier K, Kitahori Y, Hiasa Y, Nakagawa Y, Uemura H, Hirao Y, Ohnishi T, Yoshikawa K, Ooesterwijk E Activation of the MN/CA9 gene is associated with hypomethylation in humanrenal cell carcinoma cell lines. Mol Carcinog 2000 Mar;27(3):184-9.
Other key publications related to this gene
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