Human

Human Kidney Gene DataBase

Name B-factor, properdin
Symbol BF
Aliases GBG; CFAB; PBF2; C3 proactivator; C3/C5 convertase; C3 proaccelerator; glycine-rich beta-glycoprotein
Gene Product
  • complement factor B preproprotein
Category
UniGene Hs.69771 
Reference Sequence
mRNA: NM_001710 Protein: NP_001701
OMIM and SNP
OMIM: 138470 SNP: NCBI SNP
Locus
LocusLink: 629Chromosome: 6Cytoband: 6p21.3 UCSC Genome Map Eesembl Genome Map
SummaryThis gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
Gene Ontology
Expression
EST (520 ESTs, 145 libraries)
Tissue Breadth ? CPM ?
adiposeBreadth of expression: 1 out of  8 libraries express this gene (12.50%)Average CPM:0.95
boneBreadth of expression: 6 out of  24 libraries express this gene (25.00%)Average CPM:0.45
brainBreadth of expression: 4 out of  759 libraries express this gene (0.53%)Average CPM:0.63
cartilageBreadth of expression: 5 out of  16 libraries express this gene (31.25%)Average CPM:0.73
cervixBreadth of expression: 3 out of  11 libraries express this gene (27.27%)Average CPM:0.10
colonBreadth of expression: 8 out of  930 libraries express this gene (0.86%)Average CPM:0.27
eyeBreadth of expression: 4 out of  24 libraries express this gene (16.67%)Average CPM:0.22
germ cellBreadth of expression: 1 out of  6 libraries express this gene (16.67%)Average CPM:0.68
head and neckBreadth of expression: 3 out of  680 libraries express this gene (0.44%)Average CPM:10.74
heartBreadth of expression: 1 out of  26 libraries express this gene (3.85%)Average CPM:2.11
kidneyBreadth of expression: 4 out of  145 libraries express this gene (2.76%)Average CPM:17.64
liverBreadth of expression: 16 out of  65 libraries express this gene (24.62%)Average CPM:7.35
lungBreadth of expression: 10 out of  334 libraries express this gene (2.99%)Average CPM:1.00
mammary glandBreadth of expression: 9 out of  1038 libraries express this gene (0.87%)Average CPM:138.35
muscleBreadth of expression: 3 out of  83 libraries express this gene (3.61%)Average CPM:0.18
nervousBreadth of expression: 1 out of  21 libraries express this gene (4.76%)Average CPM:0.24
oral cavityBreadth of expression: 1 out of  13 libraries express this gene (7.69%)Average CPM:4.58
ovaryBreadth of expression: 5 out of  170 libraries express this gene (2.94%)Average CPM:3.40
pancreasBreadth of expression: 2 out of  20 libraries express this gene (10.00%)Average CPM:0.65
parathyroidBreadth of expression: 1 out of  2 libraries express this gene (50.00%)Average CPM:0.09
placentaBreadth of expression: 9 out of  358 libraries express this gene (2.51%)Average CPM:2.53
prostateBreadth of expression: 2 out of  309 libraries express this gene (0.65%)Average CPM:5.34
spleenBreadth of expression: 1 out of  15 libraries express this gene (6.67%)Average CPM:8.22
stomachBreadth of expression: 9 out of  310 libraries express this gene (2.90%)Average CPM:0.54
testisBreadth of expression: 1 out of  180 libraries express this gene (0.56%)Average CPM:80.13
uncharacterized tissueBreadth of expression: 16 out of  1739 libraries express this gene (0.92%)Average CPM:4.84
uterusBreadth of expression: 15 out of  236 libraries express this gene (6.36%)Average CPM:9.47
SAGE (16691342 tags, 328 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:61.83
brainBreadth of expression: 30 out of  30 libraries express this gene (100.00%)Average CPM:173.42
cerebellumBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:58.50
cervixBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:65.75
colonBreadth of expression: 8 out of  8 libraries express this gene (100.00%)Average CPM:119.85
eyeBreadth of expression: 5 out of  6 libraries express this gene (83.33%)Average CPM:134.78
foreskinBreadth of expression: 2 out of  2 libraries express this gene (100.00%)Average CPM:257.59
heartBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:201.52
kidneyBreadth of expression: 3 out of  3 libraries express this gene (100.00%)Average CPM:120.50
liverBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:1286.25
lungBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:179.49
mammary glandBreadth of expression: 18 out of  20 libraries express this gene (90.00%)Average CPM:345.18
mesothelial tissueBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:1250.68
muscleBreadth of expression: 2 out of  2 libraries express this gene (100.00%)Average CPM:111.39
nervousBreadth of expression: 1 out of  1 libraries express this gene (100.00%)Average CPM:144.35
ovaryBreadth of expression: 9 out of  10 libraries express this gene (90.00%)Average CPM:496.35
pancreasBreadth of expression: 6 out of  8 libraries express this gene (75.00%)Average CPM:250.06
prostateBreadth of expression: 14 out of  14 libraries express this gene (100.00%)Average CPM:212.60
skinBreadth of expression: 5 out of  7 libraries express this gene (71.43%)Average CPM:242.84
stomachBreadth of expression: 4 out of  4 libraries express this gene (100.00%)Average CPM:171.96
uncharacterized tissueBreadth of expression: 18 out of  20 libraries express this gene (90.00%)Average CPM:303.53
vascularBreadth of expression: 3 out of  3 libraries express this gene (100.00%)Average CPM:179.84
EvidencePolymorphism in Nephrotic Syndrome

Other key publications related to this gene


© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco