Human

Human Kidney Gene DataBase
Name parathyroid hormone-like hormone
Symbol PTHLH
Aliases HHM; PLP; PTHR; PTHRP; MGC14611; osteostatin; PTH-related protein; parathyroid-like protein; parathyroid hormone-like protein; humoral hypercalcemia of malignancy; parathyroid hormone-related protein; parathyroid hormone-like related protein
Gene Product
  • parathyroid hormone-like hormone isoform 1 preproprotein
  • parathyroid hormone-like hormone isoform 2 preproprotein
Category
UniGene Hs.89626 
Reference Sequence
mRNA: NM_198966 Protein: NP_945317
OMIM and SNP
OMIM: 168470 SNP: NCBI SNP
Locus
LocusLink: 5744Chromosome: 12Cytoband: 12p12.1-p11.2 UCSC Genome Map Eesembl Genome Map
SummaryThe protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
Gene Ontology
Expression
EST (50 ESTs, 35 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 2 out of 759 libraries express this gene (0.26%)Average CPM:2.32
colonBreadth of expression: 1 out of 930 libraries express this gene (0.11%)Average CPM:506.33
germ cellBreadth of expression: 1 out of 6 libraries express this gene (16.67%)Average CPM:7.72
head and neckBreadth of expression: 5 out of 680 libraries express this gene (0.74%)Average CPM:68.03
kidneyBreadth of expression: 3 out of 145 libraries express this gene (2.07%)Average CPM:5.03
lungBreadth of expression: 4 out of 334 libraries express this gene (1.20%)Average CPM:37.45
mammary glandBreadth of expression: 2 out of 1038 libraries express this gene (0.19%)Average CPM:55.40
ovaryBreadth of expression: 1 out of 170 libraries express this gene (0.59%)Average CPM:4.69
pancreasBreadth of expression: 2 out of 20 libraries express this gene (10.00%)Average CPM:6.76
parathyroidBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.96
prostateBreadth of expression: 2 out of 309 libraries express this gene (0.65%)Average CPM:12.59
skinBreadth of expression: 1 out of 38 libraries express this gene (2.63%)Average CPM:20.48
testisBreadth of expression: 1 out of 180 libraries express this gene (0.56%)Average CPM:1.05
uncharacterized tissueBreadth of expression: 6 out of 1739 libraries express this gene (0.35%)Average CPM:0.34
uterusBreadth of expression: 1 out of 236 libraries express this gene (0.42%)Average CPM:3.46
whole bodyBreadth of expression: 1 out of 12 libraries express this gene (8.33%)Average CPM:1.62
SAGE (1662941 tags, 36 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 9 out of 30 libraries express this gene (30.00%)Average CPM:33.24
cervixBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:65.75
colonBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:16.38
mammary glandBreadth of expression: 3 out of 20 libraries express this gene (15.00%)Average CPM:45.52
ovaryBreadth of expression: 5 out of 10 libraries express this gene (50.00%)Average CPM:45.80
prostateBreadth of expression: 3 out of 14 libraries express this gene (21.43%)Average CPM:19.51
skinBreadth of expression: 1 out of 7 libraries express this gene (14.29%)Average CPM:75.42
stomachBreadth of expression: 2 out of 4 libraries express this gene (50.00%)Average CPM:27.33
uncharacterized tissueBreadth of expression: 4 out of 20 libraries express this gene (20.00%)Average CPM:75.21
vascularBreadth of expression: 1 out of 3 libraries express this gene (33.33%)Average CPM:17.24
EvidenceCpG Methylation in Kidney Neoplasms

Other key publications related to this gene

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Department of Urology
University of California, San Francisco