Human

Human Kidney Gene DataBase
Name peroxisome proliferative activated receptor, gamma
Symbol PPARG
Aliases NR1C3; PPARG1; PPARG2; HUMPPARG; PPAR gamma
Gene Product
  • peroxisome proliferative activated receptor gamma isoform 1
  • peroxisome proliferative activated receptor gamma isoform 2
Category
UniGene Hs.387667 
Reference Sequence
mRNA: NM_138712 Protein: NP_619726
OMIM and SNP
OMIM: 601487 SNP: NCBI SNP
Locus
LocusLink: 5468Chromosome: 3Cytoband: 3p25 UCSC Genome Map Eesembl Genome Map
SummaryThe protein encoded by this gene is a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Multiple transcript variants that use alternate promoters and splicing have been identified for this gene. At least three of these variants encode the same isoform.
Gene Ontology
Expression
EST (104 ESTs, 67 libraries)
Tissue Breadth ? CPM ?
adiposeBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:1.19
boneBreadth of expression: 3 out of 24 libraries express this gene (12.50%)Average CPM:5.46
brainBreadth of expression: 1 out of 759 libraries express this gene (0.13%)Average CPM:1.11
cartilageBreadth of expression: 3 out of 16 libraries express this gene (18.75%)Average CPM:1.83
cervixBreadth of expression: 1 out of 11 libraries express this gene (9.09%)Average CPM:3.00
colonBreadth of expression: 8 out of 930 libraries express this gene (0.86%)Average CPM:4.86
germ cellBreadth of expression: 1 out of 6 libraries express this gene (16.67%)Average CPM:8.02
head and neckBreadth of expression: 1 out of 680 libraries express this gene (0.15%)Average CPM:300.48
heartBreadth of expression: 1 out of 26 libraries express this gene (3.85%)Average CPM:0.80
kidneyBreadth of expression: 5 out of 145 libraries express this gene (3.45%)Average CPM:0.50
liverBreadth of expression: 2 out of 65 libraries express this gene (3.08%)Average CPM:4.99
lungBreadth of expression: 3 out of 334 libraries express this gene (0.90%)Average CPM:1.30
mammary glandBreadth of expression: 1 out of 1038 libraries express this gene (0.10%)Average CPM:1.12
nervousBreadth of expression: 3 out of 21 libraries express this gene (14.29%)Average CPM:1.05
ovaryBreadth of expression: 2 out of 170 libraries express this gene (1.18%)Average CPM:24.65
pancreasBreadth of expression: 2 out of 20 libraries express this gene (10.00%)Average CPM:0.65
placentaBreadth of expression: 7 out of 358 libraries express this gene (1.96%)Average CPM:12.66
prostateBreadth of expression: 2 out of 309 libraries express this gene (0.65%)Average CPM:1.13
skinBreadth of expression: 1 out of 38 libraries express this gene (2.63%)Average CPM:1.19
stomachBreadth of expression: 4 out of 310 libraries express this gene (1.29%)Average CPM:1.80
uncharacterized tissueBreadth of expression: 14 out of 1739 libraries express this gene (0.81%)Average CPM:1.99
EvidencePolymorphism in Nephrotic Syndrome
  • Caramori ML, Canani LH, Costa LA, Gross JL The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2)Pro12Ala polymorphism is associated with decreased risk of diabeticnephropathy in patients with type 2 diabetes. Diabetes 2003 Dec;52(12):3010-3.

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco