| Name | fibrinogen, A alpha polypeptide |
| Symbol | FGA |
| Aliases | |
| Gene Product | - fibrinogen, alpha chain isoform alpha preproprotein
- fibrinogen, alpha chain isoform alpha-E preproprotein
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| Category | |
| UniGene |
Hs.351593
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| Reference Sequence |
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| OMIM and SNP |
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| Locus |
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| Summary | The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. |
| Gene Ontology | |
| Expression | | EST (824 ESTs, 52 libraries) |
| Tissue | Breadth ? |
CPM ? |
| cartilage |  | | | heart | | | | kidney |  | | | liver | | | | lung | | | | muscle | | | | pancreas | | | | placenta | | | | spleen | | | | stomach | | | | testis | | | | uncharacterized tissue | | | | uterus | | |
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| SAGE (6035295 tags, 107 libraries) |
| Tissue | Breadth ? |
CPM ? |
| blood | | | | brain | | | | cervix | | | | colon | | | | eye | | | | foreskin | | | | heart | | | | kidney | | | | liver | | | | lung | | | | mammary gland | | | | ovary | | | | pancreas | | | | prostate | | | | skin | | | | stomach | | | | uncharacterized tissue | | | | vascular | | |
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| Evidence | Mutation in Renal Amyloidosis
- Uemichi T, Liepnieks JJ, Alexander F, Benson MD, Uemichi T, Liepnieks JJ, Alexander F, Benson MD The molecular basis of renal amyloidosis in Irish-American andPolish-Canadian kindreds. QJM 1996 Oct;89(10):745-50.
- Uemichi T, Liepnieks JJ, Yamada T, Gertz MA, Bang N, Benson MD, Uemichi T, Liepnieks JJ, Yamada T, Gertz MA, Bang N, Benson MD, Uemichi T, Liepnieks JJ, Yamada T, Gertz MA, Bang N, Benson MD A frame shift mutation in the fibrinogen A alpha chain gene in a kindredwith renal amyloidosis. Blood 1996 May 15;87(10):4197-203.
- Uemichi T, Liepnieks JJ, Benson MD, Uemichi T, Liepnieks JJ, Benson MD Hereditary renal amyloidosis with a novel variant fibrinogen. J Clin Invest 1994 Feb;93(2):731-6.
- Benson MD, Liepnieks J, Uemichi T, Wheeler G, Correa R, Benson MD, Liepnieks J, Uemichi T, Wheeler G, Correa R Hereditary renal amyloidosis associated with a mutant fibrinogenalpha-chain. Nat Genet 1993 Mar;3(3):252-5.
Other key publications related to this gene
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