Human

Human Kidney Gene DataBase
Name fragile histidine triad gene
Symbol FHIT
Aliases FRA3B; AP3Aase; AP3A hydrolase; dinucleosidetriphosphatase; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase
Gene Product
  • fragile histidine triad gene
Category
UniGene Hs.408289  Hs.506366 
Reference Sequence
mRNA: NM_002012 Protein: NP_002003
OMIM and SNP
OMIM: 601153 SNP: NCBI SNP
Locus
LocusLink: 2272Chromosome: 3Cytoband: 3p14.2 UCSC Genome Map Eesembl Genome Map
SummaryThis gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas.
Gene Ontology
Expression
EST (68 ESTs, 29 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 32 libraries express this gene (3.12%)Average CPM:169.49
brainBreadth of expression: 2 out of 759 libraries express this gene (0.26%)Average CPM:1.39
eyeBreadth of expression: 1 out of 24 libraries express this gene (4.17%)Average CPM:1.68
germ cellBreadth of expression: 1 out of 6 libraries express this gene (16.67%)Average CPM:0.41
kidneyBreadth of expression: 3 out of 145 libraries express this gene (2.07%)Average CPM:73.53
lungBreadth of expression: 1 out of 334 libraries express this gene (0.30%)Average CPM:0.64
mammary glandBreadth of expression: 3 out of 1038 libraries express this gene (0.29%)Average CPM:8.02
muscleBreadth of expression: 1 out of 83 libraries express this gene (1.20%)Average CPM:1.38
nervousBreadth of expression: 1 out of 21 libraries express this gene (4.76%)Average CPM:4.63
pancreasBreadth of expression: 1 out of 20 libraries express this gene (5.00%)Average CPM:0.68
placentaBreadth of expression: 2 out of 358 libraries express this gene (0.56%)Average CPM:0.67
skinBreadth of expression: 1 out of 38 libraries express this gene (2.63%)Average CPM:0.69
spleenBreadth of expression: 1 out of 15 libraries express this gene (6.67%)Average CPM:1.85
testisBreadth of expression: 2 out of 180 libraries express this gene (1.11%)Average CPM:2.29
uncharacterized tissueBreadth of expression: 8 out of 1739 libraries express this gene (0.46%)Average CPM:1.65
EvidenceDeletion in Kidney Neoplasms LOH in Kidney Neoplasms
  • Velickovic M, Delahunt B, Storkel S, Grebem SK VHL and FHIT locus loss of heterozygosity is common in all renal cancermorphotypes but differs in pattern and prognostic significance. Cancer Res 2001 Jun 15;61(12):4815-9.
  • Velickovic M, Delahunt B, Grebe SK Loss of heterozygosity at 3p14.2 in clear cell renal cell carcinoma is anearly event and is highly localized to the FHIT gene locus. Cancer Res 1999 Mar 15;59(6):1323-6.

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco