| Name|| fragile histidine triad gene|
| Symbol|| FHIT|
| Aliases|| FRA3B; AP3Aase; AP3A hydrolase; dinucleosidetriphosphatase; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase|
| Gene Product|| |
- fragile histidine triad gene
| Category|| |
| Reference Sequence||
| OMIM and SNP||
| Summary||This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas.|
| Gene Ontology|
| EST (68 ESTs, 29 libraries)|
| Tissue ||Breadth ?
|| CPM ?|
| germ cell|
| mammary gland|
| uncharacterized tissue|
| Evidence||Deletion in Kidney Neoplasms
LOH in Kidney Neoplasms
- Velickovic M, Delahunt B, Storkel S, Grebem SK VHL and FHIT locus loss of heterozygosity is common in all renal cancermorphotypes but differs in pattern and prognostic significance. Cancer Res 2001 Jun 15;61(12):4815-9.
- Velickovic M, Delahunt B, Grebe SK Loss of heterozygosity at 3p14.2 in clear cell renal cell carcinoma is anearly event and is highly localized to the FHIT gene locus. Cancer Res 1999 Mar 15;59(6):1323-6.
Other key publications related to this gene