Human

Human Kidney Gene DataBase
Name ATP-binding cassette, sub-family B (MDR/TAP), member 1
Symbol ABCB1
Aliases CLCS; MDR1; P-gp; PGY1; ABC20; CD243; GP170; P glycoprotein 1; colchicin sensitivity; doxorubicin resistance; multidrug resistance 1
Gene Product
  • ATP-binding cassette sub-family B member 1
Category
UniGene Hs.21330 
Reference Sequence
mRNA: NM_000927 Protein: NP_000918
OMIM and SNP
OMIM: 171050 SNP: NCBI SNP
Locus
LocusLink: 5243Chromosome: 7Cytoband: 7q21.1 UCSC Genome Map Eesembl Genome Map
SummaryThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
Gene Ontology
Expression
EST (64 ESTs, 37 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 5 out of 759 libraries express this gene (0.66%)Average CPM:0.37
colonBreadth of expression: 3 out of 930 libraries express this gene (0.32%)Average CPM:1.98
eyeBreadth of expression: 1 out of 24 libraries express this gene (4.17%)Average CPM:1.44
kidneyBreadth of expression: 5 out of 145 libraries express this gene (3.45%)Average CPM:0.41
liverBreadth of expression: 1 out of 65 libraries express this gene (1.54%)Average CPM:4.50
mammary glandBreadth of expression: 1 out of 1038 libraries express this gene (0.10%)Average CPM:29.54
muscleBreadth of expression: 2 out of 83 libraries express this gene (2.41%)Average CPM:4.38
nervousBreadth of expression: 3 out of 21 libraries express this gene (14.29%)Average CPM:4.72
placentaBreadth of expression: 1 out of 358 libraries express this gene (0.28%)Average CPM:37.03
prostateBreadth of expression: 1 out of 309 libraries express this gene (0.32%)Average CPM:347.22
skinBreadth of expression: 1 out of 38 libraries express this gene (2.63%)Average CPM:0.41
testisBreadth of expression: 1 out of 180 libraries express this gene (0.56%)Average CPM:1.09
uncharacterized tissueBreadth of expression: 9 out of 1739 libraries express this gene (0.52%)Average CPM:18.08
uterusBreadth of expression: 1 out of 236 libraries express this gene (0.42%)Average CPM:1.62
SAGE (2211947 tags, 41 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 6 out of 30 libraries express this gene (20.00%)Average CPM:24.76
cerebellumBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:19.50
colonBreadth of expression: 5 out of 8 libraries express this gene (62.50%)Average CPM:32.13
eyeBreadth of expression: 2 out of 6 libraries express this gene (33.33%)Average CPM:17.70
kidneyBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:23.43
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:59.83
mammary glandBreadth of expression: 4 out of 20 libraries express this gene (20.00%)Average CPM:36.69
ovaryBreadth of expression: 1 out of 10 libraries express this gene (10.00%)Average CPM:20.60
pancreasBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:52.68
prostateBreadth of expression: 2 out of 14 libraries express this gene (14.29%)Average CPM:24.08
stomachBreadth of expression: 1 out of 4 libraries express this gene (25.00%)Average CPM:45.43
uncharacterized tissueBreadth of expression: 6 out of 20 libraries express this gene (30.00%)Average CPM:39.99
EvidencePolymorphism in Kidney Neoplasms

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco