Human

Human Kidney Gene DataBase
Name mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Symbol MSH2
Aliases FCC1; COCA1; HNPCC; HNPCC1; mutS (E. coli) homolog 2; mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1)
Gene Product
  • mutS homolog 2
Category
UniGene Hs.440394 
Reference Sequence
mRNA: NM_000251 Protein: NP_000242
OMIM and SNP
OMIM: 120435 SNP: NCBI SNP
Locus
LocusLink: 4436Chromosome: 2Cytoband: 2p22-p21 UCSC Genome Map Eesembl Genome Map
SummaryMSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.
Gene Ontology
Expression
EST (185 ESTs, 102 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 32 libraries express this gene (3.12%)Average CPM:3.66
boneBreadth of expression: 1 out of 24 libraries express this gene (4.17%)Average CPM:1.07
bone marrowBreadth of expression: 1 out of 22 libraries express this gene (4.55%)Average CPM:0.73
brainBreadth of expression: 10 out of 759 libraries express this gene (1.32%)Average CPM:1.34
cartilageBreadth of expression: 2 out of 16 libraries express this gene (12.50%)Average CPM:1.33
cervixBreadth of expression: 1 out of 11 libraries express this gene (9.09%)Average CPM:0.27
colonBreadth of expression: 6 out of 930 libraries express this gene (0.65%)Average CPM:0.70
earBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.43
embryoBreadth of expression: 2 out of 4 libraries express this gene (50.00%)Average CPM:1.98
eyeBreadth of expression: 2 out of 24 libraries express this gene (8.33%)Average CPM:0.35
germ cellBreadth of expression: 1 out of 6 libraries express this gene (16.67%)Average CPM:1.65
head and neckBreadth of expression: 1 out of 680 libraries express this gene (0.15%)Average CPM:11.01
heartBreadth of expression: 1 out of 26 libraries express this gene (3.85%)Average CPM:0.29
kidneyBreadth of expression: 3 out of 145 libraries express this gene (2.07%)Average CPM:0.42
liverBreadth of expression: 4 out of 65 libraries express this gene (6.15%)Average CPM:0.40
lungBreadth of expression: 5 out of 334 libraries express this gene (1.50%)Average CPM:0.37
lymph nodeBreadth of expression: 4 out of 22 libraries express this gene (18.18%)Average CPM:0.80
mammary glandBreadth of expression: 1 out of 1038 libraries express this gene (0.10%)Average CPM:308.88
muscleBreadth of expression: 2 out of 83 libraries express this gene (2.41%)Average CPM:0.51
nervousBreadth of expression: 8 out of 21 libraries express this gene (38.10%)Average CPM:11.21
ovaryBreadth of expression: 2 out of 170 libraries express this gene (1.18%)Average CPM:6.82
placentaBreadth of expression: 2 out of 358 libraries express this gene (0.56%)Average CPM:1.78
prostateBreadth of expression: 1 out of 309 libraries express this gene (0.32%)Average CPM:0.58
skinBreadth of expression: 4 out of 38 libraries express this gene (10.53%)Average CPM:0.67
stomachBreadth of expression: 8 out of 310 libraries express this gene (2.58%)Average CPM:0.30
testisBreadth of expression: 3 out of 180 libraries express this gene (1.67%)Average CPM:1.13
uncharacterized tissueBreadth of expression: 21 out of 1739 libraries express this gene (1.21%)Average CPM:0.42
uterusBreadth of expression: 1 out of 236 libraries express this gene (0.42%)Average CPM:1.94
whole bodyBreadth of expression: 1 out of 12 libraries express this gene (8.33%)Average CPM:0.22
EvidenceDeletion in System Syndrom with Kidney Involvment

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco