Human

Human Kidney Gene DataBase
Name tumor necrosis factor (TNF superfamily, member 2)
Symbol TNF
Aliases DIF; TNFA; TNFSF2; CACHECTIN; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; TNF superfamily, member 2; tumor necrosis factor, alpha (cachectin)
Gene Product
  • tumor necrosis factor alpha
Category
UniGene Hs.241570 
Reference Sequence
mRNA: NM_000594 Protein: NP_000585
OMIM and SNP
OMIM: 191160 SNP: NCBI SNP
Locus
LocusLink: 7124Chromosome: 6Cytoband: 6p21.3 UCSC Genome Map Eesembl Genome Map
SummaryThis gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Gene Ontology
Expression
EST (82 ESTs, 26 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 2 out of 32 libraries express this gene (6.25%)Average CPM:8.76
brainBreadth of expression: 1 out of 759 libraries express this gene (0.13%)Average CPM:31.19
cartilageBreadth of expression: 1 out of 16 libraries express this gene (6.25%)Average CPM:2.81
colonBreadth of expression: 1 out of 930 libraries express this gene (0.11%)Average CPM:20.43
heartBreadth of expression: 1 out of 26 libraries express this gene (3.85%)Average CPM:0.66
lungBreadth of expression: 1 out of 334 libraries express this gene (0.30%)Average CPM:0.36
lymph nodeBreadth of expression: 1 out of 22 libraries express this gene (4.55%)Average CPM:1.41
ovaryBreadth of expression: 1 out of 170 libraries express this gene (0.59%)Average CPM:2.86
placentaBreadth of expression: 1 out of 358 libraries express this gene (0.28%)Average CPM:0.91
prostateBreadth of expression: 1 out of 309 libraries express this gene (0.32%)Average CPM:7.95
stomachBreadth of expression: 1 out of 310 libraries express this gene (0.32%)Average CPM:9.70
testisBreadth of expression: 1 out of 180 libraries express this gene (0.56%)Average CPM:41.48
uncharacterized tissueBreadth of expression: 10 out of 1739 libraries express this gene (0.58%)Average CPM:96.02
SAGE (6310978 tags, 114 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:123.65
brainBreadth of expression: 19 out of 30 libraries express this gene (63.33%)Average CPM:48.17
cerebellumBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:39.00
colonBreadth of expression: 5 out of 8 libraries express this gene (62.50%)Average CPM:25.59
eyeBreadth of expression: 4 out of 6 libraries express this gene (66.67%)Average CPM:51.97
heartBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:11.85
kidneyBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:54.77
lungBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:78.53
mammary glandBreadth of expression: 11 out of 20 libraries express this gene (55.00%)Average CPM:73.51
mesothelial tissueBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:28.42
muscleBreadth of expression: 2 out of 2 libraries express this gene (100.00%)Average CPM:37.13
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:36.09
ovaryBreadth of expression: 4 out of 10 libraries express this gene (40.00%)Average CPM:66.40
pancreasBreadth of expression: 3 out of 8 libraries express this gene (37.50%)Average CPM:60.15
prostateBreadth of expression: 6 out of 14 libraries express this gene (42.86%)Average CPM:70.42
skinBreadth of expression: 1 out of 7 libraries express this gene (14.29%)Average CPM:86.48
stomachBreadth of expression: 4 out of 4 libraries express this gene (100.00%)Average CPM:32.35
uncharacterized tissueBreadth of expression: 10 out of 20 libraries express this gene (50.00%)Average CPM:33.28
vascularBreadth of expression: 2 out of 3 libraries express this gene (66.67%)Average CPM:15.18
EvidenceMutation in Kidney Neoplasms

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco