Human

Human Kidney Gene DataBase
Name ring finger protein 139
Symbol RNF139
Aliases RCA1; TRC8; HRCA1; MGC31961; multiple membrane spanning receptor TRC8; patched related protein translocated in renal cancer
Gene Product
  • ring finger protein 139
Category
UniGene Hs.28285 
Reference Sequence
mRNA: NM_007218 Protein: NP_009149
OMIM and SNP
OMIM: 603046 SNP: NCBI SNP
Locus
LocusLink: 11236Chromosome: 8Cytoband: 8q24 UCSC Genome Map Eesembl Genome Map
SummaryThe protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
Gene Ontology
Expression
EST (136 ESTs, 84 libraries)
Tissue Breadth ? CPM ?
adiposeBreadth of expression: 1 out of 8 libraries express this gene (12.50%)Average CPM:0.91
bloodBreadth of expression: 1 out of 32 libraries express this gene (3.12%)Average CPM:0.64
bone marrowBreadth of expression: 1 out of 22 libraries express this gene (4.55%)Average CPM:2.00
brainBreadth of expression: 11 out of 759 libraries express this gene (1.45%)Average CPM:1.82
cartilageBreadth of expression: 1 out of 16 libraries express this gene (6.25%)Average CPM:3.62
colonBreadth of expression: 2 out of 930 libraries express this gene (0.22%)Average CPM:0.95
eyeBreadth of expression: 3 out of 24 libraries express this gene (12.50%)Average CPM:2.28
germ cellBreadth of expression: 2 out of 6 libraries express this gene (33.33%)Average CPM:0.20
kidneyBreadth of expression: 4 out of 145 libraries express this gene (2.76%)Average CPM:1.15
liverBreadth of expression: 1 out of 65 libraries express this gene (1.54%)Average CPM:3.81
lungBreadth of expression: 5 out of 334 libraries express this gene (1.50%)Average CPM:0.51
lymph nodeBreadth of expression: 2 out of 22 libraries express this gene (9.09%)Average CPM:7.47
mammary glandBreadth of expression: 1 out of 1038 libraries express this gene (0.10%)Average CPM:1.15
muscleBreadth of expression: 3 out of 83 libraries express this gene (3.61%)Average CPM:0.68
nervousBreadth of expression: 4 out of 21 libraries express this gene (19.05%)Average CPM:2.37
ovaryBreadth of expression: 3 out of 170 libraries express this gene (1.76%)Average CPM:4.39
pancreasBreadth of expression: 1 out of 20 libraries express this gene (5.00%)Average CPM:0.34
placentaBreadth of expression: 4 out of 358 libraries express this gene (1.12%)Average CPM:0.24
prostateBreadth of expression: 5 out of 309 libraries express this gene (1.62%)Average CPM:0.79
skinBreadth of expression: 3 out of 38 libraries express this gene (7.89%)Average CPM:0.89
stomachBreadth of expression: 2 out of 310 libraries express this gene (0.65%)Average CPM:0.41
testisBreadth of expression: 7 out of 180 libraries express this gene (3.89%)Average CPM:1.16
uncharacterized tissueBreadth of expression: 12 out of 1739 libraries express this gene (0.69%)Average CPM:0.37
uterusBreadth of expression: 4 out of 236 libraries express this gene (1.69%)Average CPM:0.55
SAGE (6026000 tags, 109 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:82.44
brainBreadth of expression: 18 out of 30 libraries express this gene (60.00%)Average CPM:37.07
cerebellumBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:39.00
colonBreadth of expression: 3 out of 8 libraries express this gene (37.50%)Average CPM:18.50
eyeBreadth of expression: 3 out of 6 libraries express this gene (50.00%)Average CPM:25.27
heartBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:23.71
kidneyBreadth of expression: 3 out of 3 libraries express this gene (100.00%)Average CPM:33.88
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:14.96
lungBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:22.44
mammary glandBreadth of expression: 8 out of 20 libraries express this gene (40.00%)Average CPM:46.24
muscleBreadth of expression: 2 out of 2 libraries express this gene (100.00%)Average CPM:55.69
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:18.04
ovaryBreadth of expression: 5 out of 10 libraries express this gene (50.00%)Average CPM:117.89
pancreasBreadth of expression: 3 out of 8 libraries express this gene (37.50%)Average CPM:30.41
prostateBreadth of expression: 7 out of 14 libraries express this gene (50.00%)Average CPM:30.90
skinBreadth of expression: 1 out of 7 libraries express this gene (14.29%)Average CPM:89.02
stomachBreadth of expression: 3 out of 4 libraries express this gene (75.00%)Average CPM:35.01
uncharacterized tissueBreadth of expression: 12 out of 20 libraries express this gene (60.00%)Average CPM:46.66
vascularBreadth of expression: 3 out of 3 libraries express this gene (100.00%)Average CPM:22.80
EvidenceMutation in Kidney Neoplasms

Other key publications related to this gene

© 2004, KGDB, All Rights Reserved.
Department of Urology
University of California, San Francisco