Human

Human Kidney Gene DataBase
Name transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Symbol TAP1
Aliases APT1; PSF1; ABC17; ABCB2; RING4; D6S114E; ABC transporter, MHC 1; peptide supply factor 1; antigen peptide transporter 1; ATP-binding cassette, sub-family B, member 2; ATP-binding cassette, sub-family B (MDR/TAP), member 2; transporter, ATP-binding cassette, major histocompatibility complex, 1
Gene Product
  • transporter 1, ATP-binding cassette, sub-family B
Category
UniGene Hs.352018 
Reference Sequence
mRNA: NM_000593 Protein: NP_000584
OMIM and SNP
OMIM: 170260 SNP: NCBI SNP
Locus
LocusLink: 6890Chromosome: 6Cytoband: 6p21.3 UCSC Genome Map Eesembl Genome Map
SummaryThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
Gene Ontology
Expression
EST (405 ESTs, 177 libraries)
Tissue Breadth ? CPM ?
bloodBreadth of expression: 5 out of 32 libraries express this gene (15.62%)Average CPM:2.72
boneBreadth of expression: 5 out of 24 libraries express this gene (20.83%)Average CPM:0.62
bone marrowBreadth of expression: 1 out of 22 libraries express this gene (4.55%)Average CPM:0.67
brainBreadth of expression: 11 out of 759 libraries express this gene (1.45%)Average CPM:1.22
cartilageBreadth of expression: 3 out of 16 libraries express this gene (18.75%)Average CPM:1.12
cervixBreadth of expression: 3 out of 11 libraries express this gene (27.27%)Average CPM:2.31
colonBreadth of expression: 12 out of 930 libraries express this gene (1.29%)Average CPM:1.66
earBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:0.40
eyeBreadth of expression: 4 out of 24 libraries express this gene (16.67%)Average CPM:0.14
germ cellBreadth of expression: 2 out of 6 libraries express this gene (33.33%)Average CPM:0.07
head and neckBreadth of expression: 3 out of 680 libraries express this gene (0.44%)Average CPM:14.96
heartBreadth of expression: 1 out of 26 libraries express this gene (3.85%)Average CPM:0.07
kidneyBreadth of expression: 4 out of 145 libraries express this gene (2.76%)Average CPM:0.06
liverBreadth of expression: 5 out of 65 libraries express this gene (7.69%)Average CPM:0.18
lungBreadth of expression: 10 out of 334 libraries express this gene (2.99%)Average CPM:0.58
lymph nodeBreadth of expression: 5 out of 22 libraries express this gene (22.73%)Average CPM:0.38
mammary glandBreadth of expression: 9 out of 1038 libraries express this gene (0.87%)Average CPM:98.77
muscleBreadth of expression: 2 out of 83 libraries express this gene (2.41%)Average CPM:1.15
nervousBreadth of expression: 1 out of 21 libraries express this gene (4.76%)Average CPM:2.98
oral cavityBreadth of expression: 1 out of 13 libraries express this gene (7.69%)Average CPM:0.48
ovaryBreadth of expression: 3 out of 170 libraries express this gene (1.76%)Average CPM:0.29
pancreasBreadth of expression: 3 out of 20 libraries express this gene (15.00%)Average CPM:0.17
pineal glandBreadth of expression: 1 out of 2 libraries express this gene (50.00%)Average CPM:1.29
placentaBreadth of expression: 3 out of 358 libraries express this gene (0.84%)Average CPM:0.39
prostateBreadth of expression: 5 out of 309 libraries express this gene (1.62%)Average CPM:1.10
skinBreadth of expression: 6 out of 38 libraries express this gene (15.79%)Average CPM:0.91
spleenBreadth of expression: 2 out of 15 libraries express this gene (13.33%)Average CPM:0.93
stomachBreadth of expression: 8 out of 310 libraries express this gene (2.58%)Average CPM:0.14
testisBreadth of expression: 3 out of 180 libraries express this gene (1.67%)Average CPM:0.17
thyroidBreadth of expression: 2 out of 48 libraries express this gene (4.17%)Average CPM:1.40
uncharacterized tissueBreadth of expression: 32 out of 1739 libraries express this gene (1.84%)Average CPM:0.04
uterusBreadth of expression: 16 out of 236 libraries express this gene (6.78%)Average CPM:0.47
SAGE (5982873 tags, 116 libraries)
Tissue Breadth ? CPM ?
brainBreadth of expression: 18 out of 30 libraries express this gene (60.00%)Average CPM:33.97
colonBreadth of expression: 6 out of 8 libraries express this gene (75.00%)Average CPM:63.58
eyeBreadth of expression: 3 out of 6 libraries express this gene (50.00%)Average CPM:18.84
heartBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:23.71
kidneyBreadth of expression: 1 out of 3 libraries express this gene (33.33%)Average CPM:47.78
liverBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:29.91
lungBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:33.65
mammary glandBreadth of expression: 11 out of 20 libraries express this gene (55.00%)Average CPM:44.18
mesothelial tissueBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:85.27
muscleBreadth of expression: 2 out of 2 libraries express this gene (100.00%)Average CPM:18.57
nervousBreadth of expression: 1 out of 1 libraries express this gene (100.00%)Average CPM:18.04
ovaryBreadth of expression: 7 out of 10 libraries express this gene (70.00%)Average CPM:68.37
pancreasBreadth of expression: 4 out of 8 libraries express this gene (50.00%)Average CPM:49.57
prostateBreadth of expression: 7 out of 14 libraries express this gene (50.00%)Average CPM:47.67
skinBreadth of expression: 3 out of 7 libraries express this gene (42.86%)Average CPM:157.01
stomachBreadth of expression: 3 out of 4 libraries express this gene (75.00%)Average CPM:45.73
uncharacterized tissueBreadth of expression: 17 out of 20 libraries express this gene (85.00%)Average CPM:61.05
vascularBreadth of expression: 3 out of 3 libraries express this gene (100.00%)Average CPM:58.47
EvidencePolymorphism in Nephrotic Syndrome

Other key publications related to this gene

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Department of Urology
University of California, San Francisco